ID H0YZW0_TAEGU Unreviewed; 779 AA.
AC H0YZW0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Semaphorin 4A {ECO:0000313|Ensembl:ENSTGUP00000003845.2};
GN Name=SEMA4A {ECO:0000313|Ensembl:ENSTGUP00000003845.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000003845.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000003845.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000003845.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; H0YZW0; -.
DR STRING; 59729.ENSTGUP00000003845; -.
DR Ensembl; ENSTGUT00000003887.2; ENSTGUP00000003845.2; ENSTGUG00000003695.2.
DR GeneTree; ENSGT00940000161509; -.
DR HOGENOM; CLU_009051_8_0_1; -.
DR InParanoid; H0YZW0; -.
DR OMA; KNNETQC; -.
DR TreeFam; TF352903; -.
DR Proteomes; UP000007754; Chromosome 25.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:1904891; P:positive regulation of excitatory synapse assembly; IEA:Ensembl.
DR GO; GO:1905704; P:positive regulation of inhibitory synapse assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0010594; P:regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IEA:Ensembl.
DR GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR045791; Sema4F_C.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF15; SEMAPHORIN-4A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF19428; Sema4F_C; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 675..701
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..510
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 583..660
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 711..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 85220 MW; 3104BCEB36F6E698 CRC64;
MSRWAALGMG EAGMLVGPSW GASLPPPAMP TALRLLCGVV VPAALLCAEP LPRLAFPSGD
PRRTLTHFSQ DNISHYDIFL LDESEEELYV GARDWLLALA VGTPGSIRAK ASIMWGATDE
KTSECAFKKK SQETECFNFI RVLVALNQTH LYVCGTYAFS PACTYIHLEN FTLVPSGRGQ
PFLDGKGQCP FDPKHTYTAL LVDGELYAGT MNNFQGNEPI ISRSLGTRTL LKTDAFLRWL
SADAAFVASF SIPEDDKVYF FFEETADEFD FFEKLLVPRV ARVCKSDVGG EKLLQKKWTT
FLKAQLVCSQ TGHFPFNVIH HTFALLRHDG RADFYAVFTS QWQAGRAGSA AVCAYRQEDL
EKVFEGKYKE LNKESSRWTV YSGPDMSPRP GSCSMGASSD KALSFMKDHF LMDGKVSPMR
GQPLLVKSDV TYTRITVHET RGVSGTTYRV MFLATADGLL HKAVELSGGA HIVESIQLFA
RPEPVKNLLL APGKGILYVG YSRGVLQVPL ANCSLHRSCA ECVLARDPYC AWHSPEGSCL
PAHLATESRS AWLQDIETGS PGTLCQRGRS AAMPRSWGAP EDPAVQGLSP RLNAVVPLPC
PRRSALATYS WQQPSGARGH TVLQPDHTLV VIVQRGTAGT YTCQATENGY TWTVAQYQLR
DFGGDGMDRG TPRSYWLEFV TVTVLLAVTL TVAACLALLT YRDQLRARSK VRGCSTPHSP
PARPREKVPL NGGTGEPPAP GAATEEEEED EGSQACCLQL DGDIDVDNNR LHVPAGDRA
//
