ID H0Z1A0_TAEGU Unreviewed; 1162 AA.
AC H0Z1A0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Potassium sodium-activated channel subfamily T member 2 {ECO:0000313|Ensembl:ENSTGUP00000004338.2};
GN Name=KCNT2 {ECO:0000313|Ensembl:ENSTGUP00000004338.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000004338.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000004338.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000004338.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H0Z1A0; -.
DR STRING; 59729.ENSTGUP00000030429; -.
DR Ensembl; ENSTGUT00000004384.2; ENSTGUP00000004338.2; ENSTGUG00000004186.2.
DR GeneTree; ENSGT00940000158746; -.
DR HOGENOM; CLU_003370_0_0_1; -.
DR TreeFam; TF314283; -.
DR Proteomes; UP000007754; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF9; POTASSIUM CHANNEL SUBFAMILY T MEMBER 2; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 64..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 210..275
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 432..545
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 1005..1038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1019
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 133038 MW; 3CE062FCC8EA7A6B CRC64;
MVDLDSEVPP LPPRYRFRDL LLGDQGWQSD DRVQVEFYMN ENTFKERLKL FFIKNQRSSL
RIRLFNFSLK LLSCFLYIVR VLLDDPTQGL GWSPIIWVNR SLPLWGLQVS VAVISLFETL
LLSYLSYKGN IWEQILRIPF LLEIINAVPF IITIFWPVLR NLFIPVFLNC WLAKHALENM
INDLHRAIQR TQSAMFNQVL ILISTLLCLI FTCICGIQHL ERAGNRLTLF DSLYFCIVTF
STVGFGDVTP KIWPSKLLVV IMICVALVVL PIQFEQLAYL WMERQKSGGN YSRYRAQTEK
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DAQVRRVLQI PMWSQRVIYL
QGSALKDQDL LRAKMDNAEA CFILSSRCEV DRTAADHQTI LRAWAVKDFA PNCPLYVQIL
KPENKFHIKF ADHVVCEEEF KYAMLALNCI CPATSTLITL LVHTSRGHTA PWEAFRQLTG
TKQTLNRESQ QSPEQWQKMY GRCSGNEVYH ISLEESTFFA EYEGKSFTYA SFHAHKKFGV
CLIGVRKEDN KNILLNPGPR YIMSSTDICF YINITKEENS AFKKQEKHGK THESKLSYHG
ASRLPVHSII ASMGTVAIDL QDTGCRGASG ATLALPAEGG KEGRRPSIAP VLEVADSSSL
PTCDLLSDQS EDETTPSDDE VSAGFEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD
KGCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN PIVLLLDNPP
DMHFLDAICW FPMVYYMVGS IDNLDDLLRC GVTFAANMVV VDKESTMSAE EDYMADAKTI
VNVQTLFRLF SSLSIITELT HPANMRFMQF RAKDCYSLAL SKLEKKEREK GSNLAFMFRL
PFAAGRVFSI SMLDTLLYQS FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TEEDLWIRTY
ARLYQKLCSS TGDIPIGVYR TESQKLTTSE SREMASQSQI SISVEEWEDT KDTKEQFSCR
GNHRNSTSSD QSDHPLLRRK SMQWARRLSR RAPRHSAKTA EKINQQRMNL YRRSERQELA
ELVKNRMKHL GLSPAGYDEM NDHQNTLSYI LINPSPDTRL ELNDIVYLIR PDPLTYVPNA
GPSRKDSFCN TVGQDTREET QL
//