ID H0Z384_TAEGU Unreviewed; 1436 AA.
AC H0Z384;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Kinesin family member 15 {ECO:0000313|Ensembl:ENSTGUP00000005027.2};
GN Name=KIF15 {ECO:0000313|Ensembl:ENSTGUP00000005027.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000005027.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000005027.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000005027.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-12 subfamily.
CC {ECO:0000256|ARBA:ARBA00034488}.
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DR STRING; 59729.ENSTGUP00000005027; -.
DR Ensembl; ENSTGUT00000005077.2; ENSTGUP00000005027.2; ENSTGUG00000004823.2.
DR GeneTree; ENSGT00940000156463; -.
DR HOGENOM; CLU_005295_0_0_1; -.
DR InParanoid; H0Z384; -.
DR OMA; SEYNFKM; -.
DR OrthoDB; 2915018at2759; -.
DR TreeFam; TF320478; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01373; KISc_KLP2_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR031794; HMMR_C.
DR InterPro; IPR044986; KIF15/KIN-12.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR37739; KINESIN-LIKE PROTEIN KIN-12D; 1.
DR PANTHER; PTHR37739:SF8; KINESIN-LIKE PROTEIN KIN-12D; 1.
DR Pfam; PF15908; HMMR_C; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 64..401
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT COILED 408..435
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 468..495
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 553..583
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 744..1094
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1127..1168
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1212..1424
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 147..154
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1436 AA; 163939 MW; 758009E6A5A8FE4E CRC64;
MAAAAPGPAG GGAAPLSAKF EGAAILERRA GVAGLGAAMA PGVRGDLRDS SISSLNSASV
EGDAIKVFVR VRPPSDRTAL TDGDHGLCLS VLSSNTIRLH SKPEPKIFTF DYVANMETTQ
ESVFSSVAKN IVESCMNGYN GTIFAYGQTG SGKTFTMMGP SDSDNFTHSL RGVIPRSFEY
LFFLIEREKE KAGSGKSFLC KCSFIEIYNE QIFDLLDSAS AGLFLREHIK KGVFVDGAVE
QVLSSAAEAY QVLTTGWRNR RVASTSMNRE SSRSHAVFTI TVESMEKNSE VVNIRSSLLN
LVDLAGSERQ KDTHTEGLRL KEAGNINRSL SCLGQVITAL VDVGNGKQRH ICYRDSKLTF
LLRDSLGGNA KTCIIANVHP GSKCFGETLS TLNFAQRAKL IKNKAVVNED TQGNVSQLQA
EVKKLKEQLA QLTSVPSVCS ISVSQDTAEK GKNIINYMNN FLEAMLFWEK SEGEKKNLLE
KVAQLEELCA KKEKFVQSNK MIVKFREDHI VRLERLHKEA GGMLLPKEQD DLLSDLRKEV
QILREQMEQH PRIAKYAMEN HNLREENKKL RSLQSVKKAQ EIDAQTIAEL EKAFLEASAT
EKSTGGQRLH STMSVDGNSL ASVERLRARL LQTQAELATS KQEYEEFKEL TKKKQMELES
ELQSLQKANQ HLENILEATK AHKRREVSQL HKLRRESLKS ITTPTRAYQL RSRLVPRISP
DNNFEDFQHS EEMMDDILKE PVPLEMNEQA CEAIAEELKG AQEQLSTMQT KLDEEESKNM
KLQQHINKLE HHSAQIQELL SSERNDWSKE RQELLEQIKS LEKQLQESQN KADLLTSEVH
DLRIVLQSAD KELSDIKLEY SAFREKQEKE ISQLSGRHMD VQFQLDSVRL EHEKILEEKA
SLQDDYDNLQ EVAKFETDQL KQQLEDRKQE AEAMKSELCN LLQLLKTEKE HNEKLTLQLQ
EDKENNSKEP LKVLEKGQVE KPFSEMVTQC EQQEAKLRTL EQELAAAEET IASLKKTNDT
DKEVVTDLMR QIQELRSSIN HKTESIDGLT RELEDINYKY NIALTAKEES KGIIEDQEKK
IEELKEALEG REIADNIERD LLCEELRHTA DQLISLTEAS KKHHALLQCA QEDVAKKEAV
IQELREQLDK MTEELENRKH EYELKMKQID CFVDSSSVTF PQCPKTPPNF DVNLAKLLET
HEQEIADRRA SAINLEHLVN ELNEERRAKN DEILRLKEQL NELENLRLEM QILMENNRSL
QSLVEAQRPS KNSDQKHPDV QYLKEKEEEI AEERLAKNKA VEEMLKIKAE LEETKNILRI
QENACHEITL EMERTRTLEL RTFNEKEEIR SKLEEAYEEK DRIEKEIKLL RKQVALLAEE
NGKLLGHQNL NQKIQYLVKL KKDYAKLTEE TEKLRVENAF LKESKKCNIC RNYDQL
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