ID H0Z4J7_TAEGU Unreviewed; 1496 AA.
AC H0Z4J7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Enhancer of mRNA-decapping protein 4 {ECO:0000256|ARBA:ARBA00015762};
GN Name=EDC4 {ECO:0000313|Ensembl:ENSTGUP00000005492.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000005492.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000005492.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000005492.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the WD repeat EDC4 family.
CC {ECO:0000256|ARBA:ARBA00009639}.
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DR STRING; 59729.ENSTGUP00000005492; -.
DR Ensembl; ENSTGUT00000005546.2; ENSTGUP00000005492.2; ENSTGUG00000005312.2.
DR GeneTree; ENSGT00510000047791; -.
DR HOGENOM; CLU_005166_0_0_1; -.
DR InParanoid; H0Z4J7; -.
DR OMA; VIAMHVK; -.
DR TreeFam; TF350715; -.
DR Proteomes; UP000007754; Chromosome 11.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR Gene3D; 6.10.140.270; -; 1.
DR Gene3D; 1.10.220.100; conserved c-terminal region of ge- 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045152; EDC4-like.
DR InterPro; IPR049404; EDC4_C.
DR InterPro; IPR044938; EDC4_C_sf.
DR InterPro; IPR032401; EDC4_WD40.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15598; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR PANTHER; PTHR15598:SF5; ENHANCER OF MRNA-DECAPPING PROTEIN 4; 1.
DR Pfam; PF21289; EDC4_C; 1.
DR Pfam; PF16529; Ge1_WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 207..534
FT /note="Enhancer of mRNA-decapping protein 4 WD40 repeat
FT region"
FT /evidence="ECO:0000259|Pfam:PF16529"
FT REPEAT 386..419
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1363..1483
FT /note="Enhancer of mRNA-decapping protein 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21289"
FT REGION 72..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1042..1069
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 82..101
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1496 AA; 163511 MW; AA849283FE546350 CRC64;
MTSVAVAVVG LRAPSKPQDT FVPFAEERTG APSAPGVCAG SSAQVPRCAV CAAASLGGSR
CVRGSVCAAR RGGWGGGGAP ARPRRSRRRR SRPRRSRRRP AAPGTLRSGG GFRPALAGPG
RRRKRGRRGR AGQRGGGGAG GRRAGPHGLL LQHRHRGRHA APAGHPQAGP AGSCLSGDDS
STCLVISAKD VEVVASSDSS ITSKARGSNK VTIQPVARYD WEQKYYYGNL IAVSNSYLAY
AIRAATNGSA MVRVLSVSTA ERTLLKGFTG GVADLAFAHL NSNQLACLDE AGNLFVWRLA
MDKDKIQEEI LVNIRRPDNT PLNTFRRIIW CPFIPDDNEE SGEEGSQTLA LLHEDRAEVW
DLDIIRTNNS SWPVEVPDIK EGFIVVKGHS TCLSEGALSP DGTVLATASH DGFVKFWQIY
IEGQDEPRCL HEWKPHDGRP LSCLLFCDNH KKQDPEVPFW RFLITGADQN RELKMWCTVS
WTCLQTVRFS PDIFSSMTIL PSLKVCLDLS AEYLILSDVQ RKVLYVMELM QNQEEGKAYF
SSISEFLLTH PVLSFGIQAV SRCRLRHTEV LPAEEENDSL SVEGAQGSGA VESAAGVLIK
LFCVHTKALQ DVQIRFQPLH SPDTSASMPA HGSHEEFAFP DHMADLNTEG LGSEKESVHG
SQPDLRRIAD LPVPADFLSL SSDAKPKLMT PDAFMTPSTS LQQIAVSPGS SVSSLTAVTA
MSSASVTDTS LPRASEDLTV SPKMQLDTSL TLSSSSSSLQ TSPRSHSVLI PGLPDKLTPK
APVPVAPGNS SLALELQEVE PLVVPQASPT RERSPDVISS ASTAMSQDIP EIASETLQRS
FAAAPAGLPG EVLEPGHHAD SMASAASALH LLSPRNRHNS EHSHHSLDMP PVEVDRLNAP
SLLETALTQE NASSDSVVSQ PWPAAPDITR ETRNSMADSP RDEVEEKHKS SSYHRHSYHL
LQHDSQDASA EQSDHDDEVA SLASTSGGFG AKASAQRLPV KDWKVKASPR ASPKLKRKAK
KDDGDINQSP RSSNNQVTAE FQDEVMCMLR SQQRELSELR QNQMELLQRL TDHLDAIQSS
LMGHMERVID SQQEQEQRRL DRVLMEGQQR NGQVQEHLSQ QLSQSLSTAV CNRLERTIRE
EMKKTVPQCI SKSMDPTVSQ LSNTIATKLT AVEGTLKENI TKLVKSKNLT DSVVRATADT
LQGPIQSAYR EAFQSVVLPA FEKSCQSMFQ QINDTFKQGT QEYIQQLEAH LKNKKAREQE
VREPLLNQLR QLISTFQSTT EQLASTIAAS VHTEVQHQLH VIVGNMQESI LAQVQRVIKG
EVSLAMKEQQ AAVTSSIVQA MRSAAGTPIP STHMDFQSQQ THILQLLQQG HLNQAFQQAL
TAADLNLVLY VCETVDTQQV FGQHPCPLSQ PVLLSLIQQL SSDLGTRTEL KLNYLEDAVM
HLDQSDPITR DHMGSVMNQV RQKLFQFLQA EPHNPLSKAA RRLMIMLQGL VTPGMT
//