ID H0Z5F2_TAEGU Unreviewed; 765 AA.
AC H0Z5F2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Amyloid beta precursor protein binding family A member 2 {ECO:0000313|Ensembl:ENSTGUP00000005798.2};
GN Name=APBA2 {ECO:0000313|Ensembl:ENSTGUP00000005798.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000005798.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000005798.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000005798.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0Z5F2; -.
DR STRING; 59729.ENSTGUP00000005798; -.
DR Ensembl; ENSTGUT00000005856.2; ENSTGUP00000005798.2; ENSTGUG00000005613.2.
DR GeneTree; ENSGT00940000158943; -.
DR HOGENOM; CLU_013563_3_0_1; -.
DR InParanoid; H0Z5F2; -.
DR OMA; MSPEHSG; -.
DR TreeFam; TF315245; -.
DR Proteomes; UP000007754; Chromosome 10.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0099171; P:presynaptic modulation of chemical synaptic transmission; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01208; PTB_X11; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR PANTHER; PTHR12345:SF12; AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY A MEMBER 2; 1.
DR PANTHER; PTHR12345; SYNTENIN RELATED; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF00640; PID; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00462; PTB; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS01179; PID; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 374..561
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 574..659
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 665..734
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 85014 MW; D941EAFBA3C1318B CRC64;
MANRKHQSTA ASMLDHRARA CPTSSHNREP ENEESDLPIE DYAAKEAELA TVRAGSPTPV
EHECNDHSGD GDSSSDYVNN TSEEEDYDEG LPEEEEGITY YIRYCPEDDS YLEGMDCNGE
EYAPHEEHHV ETDECQEAVE EWAEGKIQHQ DENEVMDRQE WQEGQDNGIQ ILEDEASSLE
IQDQEENIQY CQSEGDYPDY YPAEANGNSQ GISPYHSRKE DAELEEQEED IDQIVAEIKM
SMSMSSINST TEMSPEHTGT ENMAHDYKET CSKGEAVHSA NRHEGRPKSL NIPSASKHSG
DVHRGYKAKS RSPEDRQKWP QEQMCNGLEQ PRKQQRSDLN GPADNNNPPE TKKVSSFPSF
VDVPGPCEPE DLIDGIIFAA NYLGSTQLLS ERNPSKNIRM MQAQEAVSRV KRMQKAAKIK
KKATSEGDSQ ALTEVDLFIS TQRIKVLNAD TQETMMDHAL RTISYIADIG NIVVLMARRR
MPRSASQDCI ETTPGAQEGK KQYKMICHVF ESEDAQLIAQ SIGQAFSVAY QEFLRANGIN
PEDLSQKEYS DIINTQEMYN DDLIHFSNSE NCKELQLEKQ KGEILGVVIV ESGWGSILPT
VILANMMNGG PAARSGKLSI GDQIMSINGT SLVGLPLATC QGIIKGLKNQ TQVKLNIVSC
PPVTTVLIKR PDLKYQLGFS VQNGIICSLM RGGIAERGGV RVGHRIIEIN GQSVVATAHE
KIVQALSNSV GEVREQSLYQ GSKIVEKIYV SVEKSINTAL KSPNL
//
