ID H0Z7X6_TAEGU Unreviewed; 1254 AA.
AC H0Z7X6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Potassium sodium-activated channel subfamily T member 1 {ECO:0000313|Ensembl:ENSTGUP00000006676.2};
GN Name=KCNT1 {ECO:0000313|Ensembl:ENSTGUP00000006676.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000006676.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000006676.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000006676.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H0Z7X6; -.
DR STRING; 59729.ENSTGUP00000006676; -.
DR Ensembl; ENSTGUT00000006742.2; ENSTGUP00000006676.2; ENSTGUG00000006452.2.
DR GeneTree; ENSGT00940000156880; -.
DR HOGENOM; CLU_003370_0_0_1; -.
DR InParanoid; H0Z7X6; -.
DR OMA; MMNDLNR; -.
DR TreeFam; TF314283; -.
DR Proteomes; UP000007754; Chromosome 17.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF14; POTASSIUM CHANNEL SUBFAMILY T MEMBER 1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 298..365
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 523..617
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT REGION 1227..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 142994 MW; FECC627E44610562 CRC64;
MPFSGEQRSL QGIYKAAGPA EGRPLCSECY TNRSFVYDDG SAHRLSSPGG CGGGDGGGSR
KSGVILDIAS LKMTELESEV LPLPPRYRFR DLLLGDQSFQ SDDRVQVEFY VNENTFKERL
KLFFIKNQRS SLRIRLFNFS LKLLTCLLYI VRVLLDNPEE GIGCWECEKQ NYTAFNQSTN
INWSHIFWVD RKTPLWAVQV SIALISFLET MLLTYLSYKG NIWEQIFRIS FVLEMINTVP
FIITIFWPPL RNLFIPVFLN CWLAKYALEN MINDLHRAIQ RTQSAMFNQV LILICTLLCL
VFTGTCGIQH LERAGEKLSL FKSFYFCIVT FSTVGYGDVT PKIWPSQLLV VIMICVALVV
LPLQFEELVY LWMERQKSGG NYSRHRAQTE KHVVLCVSSL KIDLLMDFLN EFYAHPRLQD
YYVVILCPTE MDIQVRRVLQ IPLWSQRVIY LQGSALKDQD LMRAKMDNGE ACFILSSRNE
VDRTAADHQT ILRAWAVKDF APNCPLYVQI LKPENKFHVK FADHVVCEEE CKYAMLALNC
VCPATSTLIT LLVHTSRGQE GQESPEQWQR MYGRCSGNEV YHIRMGDSKF FMEYEGKSFT
YAAFHAHKKY GVCLIGIRRE ENKSILLNPG PRHIMAASDT CFYINITKEE NSAFIFKQEE
KQKKKGFAGR GSYDGPSRLP VHSIIASMGT VAMDLQNTEC RPANSSKLAL PAENGSGTRR
PSIAPVLELA DTSSLLPCDL LSDQSEDEMT QSDEEGSAVV EYVKGYPPNS PYIGSSPTLC
HLLPEKAPFC CLRLDKGCKH NSFEDAKAYG FKNKLIIVSA ETAGNGLYNF IVPLRAYYRS
RKELNPIVLL LDNKPEHHFL EAICCFPMVY YMEGTIDNLD SLLQCGIIYA DNLVVVDKES
TMSAEEDYMA DAKTIVNVQT MFRLFPSLSI ITELTHPSNM RFMQFRAKDS YSLALSKLEK
RERENGSNLA FMFRLPFAAG RVFSISMLDT LLYQSFVKDY MITITRLLLG LDTTPGSGYL
CAMKITEDDL WIRTYGRLFQ KLCSSSAEIP IGIYRTESHM FATSEPHDIR AQDCEDTKDV
KEHWGIKTSH HRNSCSSDQS EHPLLRRKSM QWARRLSRKG NKHSSKTAEW ISQQRLSLYR
RSERQELSEL VKNRMKHLGL PTTGYEDVAN LTASDVMNRV NLGYLQDEMN DHQNTLSYVL
INPPPDTRLE LNDIVYLIRS DPLAHVANDG HSRKSSCSNK LGSCNPETRD ETQL
//