ID   H0Z8H3_TAEGU            Unreviewed;       203 AA.
AC   H0Z8H3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=TRAF-type zinc finger domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040410};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000006876.2, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000006876.2, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA   Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA   Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA   Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA   McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA   Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA   Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA   Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA   Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA   Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA   Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000006876.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC       immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC       DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC       by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC       activation. May negatively regulate the RLH pathway downstream from
CC       MAVS and upstream of NF-kappa-B and IRF3.
CC       {ECO:0000256|ARBA:ARBA00037636}.
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DR   AlphaFoldDB; H0Z8H3; -.
DR   STRING; 59729.ENSTGUP00000006876; -.
DR   Ensembl; ENSTGUT00000006945.2; ENSTGUP00000006876.2; ENSTGUG00000006695.2.
DR   GeneTree; ENSGT00530000063869; -.
DR   HOGENOM; CLU_078695_1_0_1; -.
DR   InParanoid; H0Z8H3; -.
DR   OMA; HCGEMVA; -.
DR   Proteomes; UP000007754; Chromosome 15.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR   InterPro; IPR049439; TRAFD1-XIAF1_Znf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR16295:SF19; TRAF-TYPE ZINC FINGER DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR16295; TRAF-TYPE ZINC FINGER PROTEIN-RELATED; 1.
DR   Pfam; PF21366; TRAFD1-XIAF1_ZnF; 1.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT   DOMAIN          89..131
FT                   /note="TRAFD1/XAF1 zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF21366"
FT   REGION          125..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   203 AA;  22353 MW;  B46096D6D5639F9A CRC64;
     QLGNFGVQRS VVTAGALINF IIHEIHCRRN IEICPYCSDS IPKSEMKNHI ESEHVQVTCK
     CRMKMESSLL KDHEASSCPL RPVLCQFCDI QLAFKELQEH ELYCGARTEP CGRCGRNVLR
     RELPEHPRLC GSDRSTAGDS GGTAPAPGRQ RGAGSGRHGA GTAGAWEEPE REKEIWSGCG
     TQLQAQNPLR DTTPGTEPLR TES
//