ID H0Z981_TAEGU Unreviewed; 1011 AA.
AC H0Z981;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Spliceosome associated factor 3, U4/U6 recycling protein {ECO:0000313|Ensembl:ENSTGUP00000007134.2};
GN Name=SART3 {ECO:0000313|Ensembl:ENSTGUP00000007134.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007134.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007134.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007134.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0Z981; -.
DR STRING; 59729.ENSTGUP00000007134; -.
DR Ensembl; ENSTGUT00000007204.2; ENSTGUP00000007134.2; ENSTGUG00000006905.2.
DR GeneTree; ENSGT00900000141107; -.
DR HOGENOM; CLU_007172_0_0_1; -.
DR InParanoid; H0Z981; -.
DR OMA; LWARYIL; -.
DR OrthoDB; 2879516at2759; -.
DR TreeFam; TF317554; -.
DR Proteomes; UP000007754; Chromosome 15.
DR GO; GO:0015030; C:Cajal body; IEA:Ensembl.
DR GO; GO:0071001; C:U4/U6 snRNP; IEA:Ensembl.
DR GO; GO:0005691; C:U6atac snRNP; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0030621; F:U4 snRNA binding; IEA:Ensembl.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:Ensembl.
DR GO; GO:0030624; F:U6atac snRNA binding; IEA:Ensembl.
DR GO; GO:1990381; F:ubiquitin-specific protease binding; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048872; P:homeostasis of number of cells; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:Ensembl.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:Ensembl.
DR CDD; cd12391; RRM1_SART3; 1.
DR CDD; cd12392; RRM2_SART3; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR008669; LSM_interact.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034217; SART3_RRM1.
DR InterPro; IPR034218; SART3_RRM2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR17204:SF25; EMBRYO DEFECTIVE 140; 1.
DR PANTHER; PTHR17204; PRE-MRNA PROCESSING PROTEIN PRP39-RELATED; 1.
DR Pfam; PF16605; LSM_int_assoc; 1.
DR Pfam; PF05391; Lsm_interact; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00386; HAT; 7.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 752..830
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 849..926
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 54..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..131
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1011 AA; 114183 MW; 8913141244C3C2BA CRC64;
MATQRAARGA ACAAEQKTKG QAVAALGAAL PRCAGQCGAG GGLRIPVLPA RFGRRWGGTA
GRAARGQPRR AAERGGRRAE LHKMAAAGAE AAAEEEKRLP EGDPESGGDS DDEGDSDSSG
DGEDEEKENE AEIQRLEEQL SINAFDYNCH LDLIKLLRQE GELVKLRRAR QKMSELFPLT
EEIWLDWLKD EIKMASEISE REKVYELFER AVKDYICPEI WLEYAQYSIG GIGQEGGIEK
VRSIFERALT AVGLHVTKGT ALWEAYREFE NAILETAQPA PGSIPSPEQQ QVLCSQLDKI
HTLFRRQLGI PLLDMEASYA EYEEWSEEPI PETTIKNYKK ALQQLEKCKP YEEALLGAET
PKLAEYQAYI DFEMKAGDPA RIQLIYERAL AENCLVPDLW ARYNQYLDRQ LKVKELVLSA
HDRAVRNCPW TVGLWIRYLL AMERHRVEHS IISEMFEKAL NAGFIQATDY VEIWQAYLDY
LRRRVDFTQD SSKELEELRS TFARAVEYLK QEVEERFSES GDPSCTIMQN WARVEARLCN
NMQKARELWD NIMTKGNAKY ANMWLEYYNL ERAHGDTQHC RKALHRAVQC TSDYPEHVCE
VLLTLERIEG TLEDWDAAVQ KTENRLARVN EQRAKAAEKE AALAKQEEER AEQRKQARAE
KKASKKAKKT KIGDKRKADE DDEGEWGQEE ELPSKRHRGE GDGVLPEEDM EVETGLFGRG
EKPDGPAGPK EKASTSRKDI PKVLHDSSKD KVTVFVSNLS YTMAEPEAKL RELFGSCGEV
VDIRAVFNNK GTFRGYCYVQ FREEEAARQA LALDRTAVEG RPMFVSPCVD KNKNPDFKVF
RYSTTLEKHK LFISGLPFSC TKEELEEVCK AHGNVKDIRL VTNRAGKPKG LAYVEYESEA
QASQAVLKMD GLTMKDHVIK VMISNPPLRK LPDRPEPGRA SLPMAPRQIY GARGKGRTQL
SMMPRALQRQ SNPVAKAENG MVQNSPAASS DPPAEPKKMS NADFAKMLLK K
//
