ID H0Z9C8_TAEGU Unreviewed; 1065 AA.
AC H0Z9C8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=RAB GTPase activating protein 1 {ECO:0000313|Ensembl:ENSTGUP00000007181.2};
GN Name=RABGAP1 {ECO:0000313|Ensembl:ENSTGUP00000007181.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007181.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007181.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007181.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0Z9C8; -.
DR STRING; 59729.ENSTGUP00000032945; -.
DR Ensembl; ENSTGUT00000007251.2; ENSTGUP00000007181.2; ENSTGUG00000006934.2.
DR GeneTree; ENSGT00940000157216; -.
DR HOGENOM; CLU_007394_0_0_1; -.
DR TreeFam; TF317184; -.
DR Proteomes; UP000007754; Chromosome 17.
DR CDD; cd01211; PTB_Rab6GAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR PANTHER; PTHR47219:SF6; RAB GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00640; PID; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 151..266
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 562..748
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 796..961
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 989..1037
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 121219 MW; 499D65E3C965FA2D CRC64;
MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IVGNGSEQQL
QRELEDVLMD PPMEDQSSDQ DHGEVRTDGD GEEPVVLEAS ASSTINPVSV AGLQKPEMSL
PVKPSQGDCE DLSPFTPVTD EDSVVFSKLT YLGCASVNAP RSEVEALRMM SILRGQCQIS
LDVTLSVPNV SEGTVRLLDP QTNTEIANYP IYKILFCVRG HDGTPESDCF AFTESHYNAE
LFRIHVFRCE IQEAVSRILY SFATAFRRSA KQTPLSATAT PQTPDSDIFT FSVSLEIKED
DGKGYFSAVP KDKDRQCFKL RQGIDKKIVI YVQQTTNKEL AIERCFGLLL SRGKDVRSGD
MHLLDLESMG KSSDGKSYVI TGSWNQKSPH FQFVNEETPK DKVLFMTTAV DLVITEVQEP
VRFILETKVR VCSPNERLFW PFSKRSSTEN FFLKLKQIKQ KDRKNNSDTL YEVVCLESES
ERERRKTTAS PSLRLPQSGS QGSMIPSPPE DDEEEDNDEP LLSGSGDVSK ECAEKILETW
GELLHLNLSV RPKTLSALVR SGVPEALRGE VWQLLAGCHN NDHLVEKYRI LITKESPQDS
AITRDINRTF PAHDYFKDTG GDGQDSLYKI CKAYSVYDEE IGYCQGQSFL AAVLLLHMPE
EQAFSVLVKI MFDYGLRELF KQNFEDLHCK FYQLERLMQE YIPDLYNHFL DISLEAHMYA
SQWFLTLFTA KFPLYMVFHI IDLLLCEGIS VIFNVALGLL KTTKDDLLLT DFEGALKFFR
VQLPKRYRSE ENAKKLMELA CNMKISQKKL KKYEKEYHTM REQQAQQEDP IERFERENRR
LQEANMRLEQ ENDDLAHELV TSKIALRKDL DNAEEKADAL NKELLMTKQK LIDAEEEKRR
LEEESAQLKE MCRRELDKAE SEIKKNSSII GDYKQICSQL SERLEKQQTA NKAEIEKIRQ
KVDDCEHCRE FFNKEGRVKV ASTAKDGSDE DTDEEKETLK NQLREMELEL AQTKLQLVEA
ECKIQDLEHH LGLALNEVQA AKKTWFNRTI SSIKTVTGVQ GKETC
//
