ID H0Z9K0_TAEGU Unreviewed; 1080 AA.
AC H0Z9K0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|Ensembl:ENSTGUP00000007253.2};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSTGUP00000007253.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007253.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007253.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007253.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; H0Z9K0; -.
DR Ensembl; ENSTGUT00000007325.2; ENSTGUP00000007253.2; ENSTGUG00000006931.2.
DR GeneTree; ENSGT00940000157657; -.
DR HOGENOM; CLU_001883_1_2_1; -.
DR TreeFam; TF313657; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 114..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..598
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..294
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 413..691
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 705..821
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 821..1080
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1080 AA; 120032 MW; 56699A6E59CC5F13 CRC64;
MPTSFTVVPV ETQGEERQRD GQLREEEDED NERDRGAGDG IARESSPFID CAELGRGNMY
EGKNMALFEE EMDSNPMVSS LLNKLANYTN LTQGVVEHEA DEDSKRKEVK GPRMGTFIGV
YLPCLQNILG VILFLRLTWI VGTAGVLESF IIVFMCCACT MLTAISMSAI ATNGVVPAGG
SYYMISRSLG PEFGGAVGLC FYLGTTFAGA MYILGTIEIL LTYISPSAAI FKVADVGEET
EAMLNNMRVY GTCIVILMAI VVFVGVKYVN KLALVFLACV ILSIIAIYAG VIKTAFDPPD
FPICLLGNRT LSKRNFDVCA KFTESNNETK TTPLWHLFCD SSLLNATCDD YFSLNNVTEI
QGIPGIMSGV LTDNLWSAYS EKGSIIEKKD QPSVAGSEES KMGGLPYVFT DIMTYFTMLV
GIYFPSVTGI MAGSNRSGDL KDAQKSIPTG TILAISTTSF IYLSCIVLFG ACIEGVILRD
KFGEAVNGNL VVGTLAWPSP WVIVIGSFFS TCGAGLQSLT GAPRLLQAIA RDGIVPFIQI
FGHGKANGEP TWALLLTVGI CEIGILIASL DSVAPILSMF FLMCYMFVNL ACAVQTLLRT
PNWRPRFKYY HWTLSFLGMS LCLALMFICS WYYALIAMLI AGCIYKYIEY RGAEKEWGDG
IRGLSLNAAR YALLRVEDGP PHTKNWRPQL LVLLNLDNEQ LVKHPRLLSF TSQLKAGKGL
TIVGSVLQGI YLDKCTETQK AEENVKALMG VEKTKGFCQI VVSPNFRDGI SYLIQSAGLG
GMKHNTVLMA WPQSWKQAEN RFSWKNFVDT VRETTAAQQA LLVAKNIDLF PTNQERFTEG
NIDVWWIVHD GGMLMLLPFL LRQHKVWRKC KMRIFTVAQM DDNSIQMKKD LQMFLYHLRL
NAQVEVVEMF ENDISAFTYE KTLMMEQRSQ MLKQMQLSKN EREREAQLIH DKNTASRSAP
AAEASVAAAV PEKVQMTWTK EKFVAEKHKN KDSNVSGFKD IFNMKPNQSN VRRMHTAVKL
NGVVLNKSQH AQLVLLNMPG PPKNRKGDEN YMEFLEVLTE GLDRVLLVRG SGREVITIYS
//
