ID H0Z9M2_TAEGU Unreviewed; 932 AA.
AC H0Z9M2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Nuclear transcription factor, X-box binding 1 {ECO:0000313|Ensembl:ENSTGUP00000007275.2};
GN Name=NFX1 {ECO:0000313|Ensembl:ENSTGUP00000007275.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007275.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007275.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007275.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR AlphaFoldDB; H0Z9M2; -.
DR STRING; 59729.ENSTGUP00000007275; -.
DR Ensembl; ENSTGUT00000007347.2; ENSTGUP00000007275.2; ENSTGUG00000007055.2.
DR GeneTree; ENSGT00940000156325; -.
DR HOGENOM; CLU_005714_1_1_1; -.
DR InParanoid; H0Z9M2; -.
DR OMA; CECGRTX; -.
DR TreeFam; TF105889; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR CDD; cd06008; NF-X1-zinc-finger; 6.
DR CDD; cd16696; RING-CH-C4HC3_NFX1; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00184; RING; 1.
DR SMART; SM00438; ZnF_NFX; 9.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 369..426
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 372..424
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 104298 MW; 543F94C928BB061A CRC64;
MAEARPGSGT LSFSPGAADS IPGEGQPTDI NWVNKDRKDS NSDQNRSNIP IPSLYSERGT
DYESSSTKHH GFCNLESQYE NSEDFHQYFG TSKSLKNRSL QSQRLHRLRN DGTCAKNKTR
QSTADAAAGP GISDAALVPG RRAPHRGYSD ILSSESDREV PNVDSRGAKP KKTHLMHMSG
RGIREKGKQV HDGEKRVSSK QKVELFEKFP SLDLTQSDSS ESSVGKAFCD APFGSGDEQK
GYNNVNKRYP RKPVWNKPPV EKECQKRHDS HRSKNTKVGK KSSVAYTPKD KNERKKELIA
HKNDENLTSE IRHQLSESLR VSGRKFLLKG DQVPSLHFSW TQYWKKQSDV PKNKETHTGS
LIEQLTTEKY ECMVCCEVVR IVAPVWSCQN CYHVFHLNCI KKWARSPASQ AEDGNSGWRC
PACQNASVQV PKIYTCFCGK VHNPEWNRNE IPHSCGELCG KKRQCLDCPH LCNILCHPGP
CPSCPAFVTK TCECGQTSHS VRCGQSTKIH CSNVCGNTLN CGKHSCTQVC HAGKCSPCQL
TVQQVCYCGS NFKEVLCGSK EEFSDSFGSF SCQNICGKKL NCGRHNCKQV CHPQPCQLCP
RLPQVVYRCP CGQTPLSKLL ELGCVERKIC TDPIPSCGKT CGKPLSCGSY EFVHTCESLC
HEGDCRPCSH TSNIYCRCGF KKKEIPCALL RNKAAITFMC DKRCNKKRSC GRHKCNEVCC
VDTEHKCSLV CGRKLNCGLH RCEEPCHRGS CQTCWQTSFD ELTCYCGESV IYPPVPCGTQ
PPECKKTCTR PHDCDHPVYH SCHSEEKCPP CTYLTQKWCM GKHELRSNIP CHLTDISCGL
RCNQMLKCGM HKCKRICHKG ECLIDEECKQ PCIIPRLYCN HPCMAPCHPN SHCPTTSCSA
KVDLQCECGR RKESMICSEA SNTYQSCYIY SN
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