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Database: UniProt
Entry: H0ZA59_TAEGU
LinkDB: H0ZA59_TAEGU
Original site: H0ZA59_TAEGU 
ID   H0ZA59_TAEGU            Unreviewed;       392 AA.
AC   H0ZA59;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 59.
DE   SubName: Full=VPS37A subunit of ESCRT-I {ECO:0000313|Ensembl:ENSTGUP00000007462.2};
GN   Name=VPS37A {ECO:0000313|Ensembl:ENSTGUP00000007462.2};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007462.2, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000007462.2, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA   Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA   Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA   Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA   McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA   Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA   Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA   Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA   Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA   Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA   Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000007462.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC       trafficking process. Required for the sorting of endocytic
CC       ubiquitinated cargos into multivesicular bodies. May be involved in
CC       cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004633}.
CC   -!- SIMILARITY: Belongs to the VPS37 family.
CC       {ECO:0000256|ARBA:ARBA00007617}.
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DR   AlphaFoldDB; H0ZA59; -.
DR   STRING; 59729.ENSTGUP00000007462; -.
DR   Ensembl; ENSTGUT00000007538.2; ENSTGUP00000007462.2; ENSTGUG00000007239.2.
DR   GeneTree; ENSGT00950000183012; -.
DR   HOGENOM; CLU_062319_0_0_1; -.
DR   InParanoid; H0ZA59; -.
DR   OMA; HIKECLR; -.
DR   OrthoDB; 3677578at2759; -.
DR   TreeFam; TF332146; -.
DR   Proteomes; UP000007754; Chromosome 4.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000813; C:ESCRT I complex; IEA:Ensembl.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:Ensembl.
DR   Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR029012; Helix_hairpin_bin_sf.
DR   InterPro; IPR009851; Mod_r.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR   PANTHER; PTHR13678:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A; 1.
DR   Pfam; PF07200; Mod_r; 1.
DR   SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS51314; VPS37_C; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|PROSITE-
KW   ProRule:PRU00646}; Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW   ProRule:PRU00646}.
FT   DOMAIN          303..392
FT                   /note="VPS37 C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51314"
FT   COILED          257..316
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   392 AA;  43927 MW;  1DAEA9F19E99147A CRC64;
     MNWLFPLAKG GAAPAAPPAR TGLQQQRQRQ VESLRAAHAS IAEIQKDVEY RLPFTVNNLT
     ININILLPPQ FPQEKPVISV FPPVRHHLMD KQGVYVTGPL ISNFTMHSDL GKIIQSLLDE
     FWKNPPVLAP SSTSFPYLFN KPAGMPPFAP QGFPFLPPYP PQETNRTMAP MPISESVSSS
     YTTDKPAAPS YGLIADLPLP VPTAEAVLQV GQNGFTYKMP DVPDTFPELS ELSISQLTSM
     NEQEEVLLEQ FVTLPQLKQV ITDRDELVKS IEELAKKNLL LEPSLEAKRQ TVLDKYEQLT
     QMKAAFEKKM QRQHELSESC SPSALQARLK VAAHEAEEES DTIAEDFLEG KTEIDDFLSS
     FMEKRTLCHC RRAKEEKLQQ AIAMHSQFHA PL
//
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