ID H0ZAI4_TAEGU Unreviewed; 165 AA.
AC H0ZAI4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit 6 {ECO:0000256|ARBA:ARBA00019579, ECO:0000256|PIRNR:PIRNR037609};
DE Short=BLOC-1 subunit 6 {ECO:0000256|PIRNR:PIRNR037609};
GN Name=BLOC1S6 {ECO:0000313|Ensembl:ENSTGUP00000007588.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007588.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007588.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007588.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the BLOC-1 complex, a complex that is required
CC for normal biogenesis of lysosome-related organelles (LRO), such as
CC platelet dense granules and melanosomes. In concert with the AP-3
CC complex, the BLOC-1 complex is required to target membrane protein
CC cargos into vesicles assembled at cell bodies for delivery into
CC neurites and nerve terminals. The BLOC-1 complex, in association with
CC SNARE proteins, is also proposed to be involved in neurite extension.
CC May play a role in intracellular vesicle trafficking, particularly in
CC the vesicle-docking and fusion process.
CC {ECO:0000256|PIRNR:PIRNR037609}.
CC -!- SIMILARITY: Belongs to the BLOC1S6 family.
CC {ECO:0000256|ARBA:ARBA00005767, ECO:0000256|PIRNR:PIRNR037609}.
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DR AlphaFoldDB; H0ZAI4; -.
DR STRING; 59729.ENSTGUP00000007588; -.
DR Ensembl; ENSTGUT00000007666.2; ENSTGUP00000007588.2; ENSTGUG00000007369.2.
DR GeneTree; ENSGT00510000047812; -.
DR HOGENOM; CLU_2114568_0_0_1; -.
DR InParanoid; H0ZAI4; -.
DR OMA; MMSDVKR; -.
DR Proteomes; UP000007754; Chromosome 10.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0031083; C:BLOC-1 complex; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0031201; C:SNARE complex; IEA:Ensembl.
DR GO; GO:0030133; C:transport vesicle; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0048490; P:anterograde synaptic vesicle transport; IEA:Ensembl.
DR GO; GO:0007596; P:blood coagulation; IEA:Ensembl.
DR GO; GO:0035646; P:endosome to melanosome transport; IEA:Ensembl.
DR GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
DR GO; GO:0032402; P:melanosome transport; IEA:Ensembl.
DR GO; GO:0061025; P:membrane fusion; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR GO; GO:0032816; P:positive regulation of natural killer cell activation; IEA:Ensembl.
DR GO; GO:0050942; P:positive regulation of pigment cell differentiation; IEA:Ensembl.
DR GO; GO:0033299; P:secretion of lysosomal enzymes; IEA:Ensembl.
DR InterPro; IPR017242; BLOC-1_pallidin.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR PANTHER; PTHR31328; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR PANTHER; PTHR31328:SF2; BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6; 1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PIRSF; PIRSF037609; BLOC-1_complex_pallidin; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 165 AA; 18819 MW; 0ECEB511507B4492 CRC64;
MSGAERPEGK EAAAVGDPGP PSDASPDEGV VEDLPLIDEK AVEQLTEGLI SHYLPDLQRS
KSALQELTQN QVVLLETLEQ EISKFKECNS IGHINALFSE AKHYHNKLVN IRNEMMMLHE
KTSKLKKRAL KLQQKRQKEE LEREQQREKE LEREKQLTAK PAKRT
//