ID H0ZBE2_TAEGU Unreviewed; 794 AA.
AC H0ZBE2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=WASP homolog associated with actin, golgi membranes and microtubules {ECO:0000313|Ensembl:ENSTGUP00000007900.2};
GN Name=WHAMM {ECO:0000313|Ensembl:ENSTGUP00000007900.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000007900.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000007900.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000007900.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; H0ZBE2; -.
DR STRING; 59729.ENSTGUP00000007900; -.
DR Ensembl; ENSTGUT00000007985.2; ENSTGUP00000007900.2; ENSTGUG00000007672.2.
DR GeneTree; ENSGT00510000046704; -.
DR HOGENOM; CLU_012316_1_0_1; -.
DR InParanoid; H0ZBE2; -.
DR OMA; IQFYEIQ; -.
DR OrthoDB; 5354952at2759; -.
DR TreeFam; TF331023; -.
DR Proteomes; UP000007754; Chromosome 10.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0071933; F:Arp2/3 complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0048041; P:focal adhesion assembly; IEA:Ensembl.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0097320; P:plasma membrane tubulation; IEA:Ensembl.
DR GO; GO:0051127; P:positive regulation of actin nucleation; IEA:Ensembl.
DR Gene3D; 6.10.280.150; -; 1.
DR InterPro; IPR031738; JMY/WHAMM.
DR InterPro; IPR031808; JMY/WHAMM_N.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR23330; P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED; 1.
DR PANTHER; PTHR23330:SF6; WASP HOMOLOG-ASSOCIATED PROTEIN WITH ACTIN, MEMBRANES AND MICROTUBULES; 1.
DR Pfam; PF15871; JMY; 1.
DR Pfam; PF15920; WHAMM-JMY_N; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 728..745
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 464..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 335..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 556..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..660
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 89566 MW; F5AE0020D8FABA93 CRC64;
MEPQPDSLEG WVAVRDTAFA EPQPPPRLRF LVGWNGAEGA FAVTCHGRAE AAEQAPQSWA
GLFSAPALRG VHRQLSAVCP RLEPAFPELP PALPGAASGG LWAVLFPGGA APGEAELQEL
CRALELYLGW ALELCGGRVV LDVLFAADRC CDDEYFESLH ELRGKALRGH LARAKEALRR
VLQQHKSADT MVALMKVYEE EDEAYQDLVT MATQFYQYLL QPFRDMRELA TLYKLEILKS
LQYDNLGPRR VAALQKDADE WTKRAESAVC SIQDITVNYF KETVKALAAM HKQMEQDEER
FGKTTWASAL PRLENLKYML AKETLQHLRA RELCLKQKRT GIQKLMENLG EQEENLSIVE
ELEIQYYETQ LELYNVQLEV LKHEEMLLIV QLDTIKRQIK EKQDEVVYYD TCENPEELKV
IEQTMGQHYA NLSAMTVLRQ KTKQLETKRG TVCARRAYLR NKKDQCEASH RQRLQQAEES
RKRFQQHHSI QIKRDKQKEE EKKKKAWISQ ERQKTLERLK VFREKCPAHV VLKTSRPQPH
SPKLPQGIPQ QAVVLSPPPA SSTGTAPAVL SPAPSSRVRT ALEQPQSILL VEDEEPKASC
QNTPPADIPV QIFVTDGDTE EQKHSEELMV SPCSPPPPPP PPPPPPPLPP PPPPPSLPLQ
LKPSATEDKP LPLSSDSPSE SPALHNQDDS SRRSINNCIG SMDEVLASLK RTEVHLRKVE
EPNPYASVKD NILSAIRQGV KLRKVNRDSE RDVSRGSPNE LEKSIKAAMQ RIKKVSADSE
EEEDNDQNNG EWDS
//
