ID H0ZBT1_TAEGU Unreviewed; 770 AA.
AC H0ZBT1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008039.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008039.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008039.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR AlphaFoldDB; H0ZBT1; -.
DR Ensembl; ENSTGUT00000008124.2; ENSTGUP00000008039.2; ENSTGUG00000007810.2.
DR GeneTree; ENSGT00940000159520; -.
DR HOGENOM; CLU_002274_2_3_1; -.
DR OMA; NVYSFTH; -.
DR Proteomes; UP000007754; Chromosome 5.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 76..279
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 85212 MW; 76BA45ACF3852B22 CRC64;
MGWESRQDRE LGACPRESPS FHSRFTPLTI TREPRGKHGA KDGAVGTGQG CASAGSGAAA
ATTALFEPGG DGQTPQVVVL VGAPGMGKTT MVRKVMVEWG EGTLHTQFDF VFCIDCKAIT
LPMEASVADL VSQCCPALQV PAGKILDDQK KILFIFDGFE ALGFSLVQPE AELSSDPREV
KPLELTLMSL LKKTVLPKAS LLITMRPMAL GSLRQCLKGK HYMEILGFSA ARRKEYFHQY
FENPRKADVA FRFVRGNEIL YSLCVIPIMS WTICTILEQE LCGKKNLLEC SKATTGMTMF
YLSQLLKHRG RDNPQVLQQF LLQLCSLAAE GIWKHKVLFE EKEIKDYGLD QPGLLPYFLN
ERIPRKGEDN GSVYAFTHLH LQEFFAALFY VLEDDGETVS SSGRLEKDVN KLLESYKSRK
DLNVTVLFLF GLVSQKSMEY MDKTFGCRIS PRAREELLEW LQGRHRGLSH PSQALKISEM
DTFHFLFEMN EKSFAESALG HFTDLDLHDT KLTLYDQMAL SFCIQHWAGL GSITLQGCFF
HWQDPEAELD ASVPCSGVSG AGGHPGALVV QRKEEMPCPI HLLCRALRHR DSALQVLRLQ
WCQLSESCCA ELAALLAEHP GLAHLEVADS SLGDSGVRLL CEGLRTAGSR LRILRLRYTR
ITSASCEDLA AVLGTNTCLE ELDLSFSEDL RDTGVELLCE GLQHCACPLQ ILRLGSCRLA
GASCPALAAR LLHGPRLTCL DLSDNELGAH GVLQLCQQLR HPACPLRSLG
//
