ID H0ZC33_TAEGU Unreviewed; 331 AA.
AC H0ZC33;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=von Willebrand factor C domain containing 2 {ECO:0000313|Ensembl:ENSTGUP00000008141.1};
GN Name=VWC2 {ECO:0000313|Ensembl:ENSTGUP00000008141.1};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008141.1, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008141.1, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008141.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012427275.1; XM_012571821.1.
DR RefSeq; XP_012427276.1; XM_012571822.1.
DR AlphaFoldDB; H0ZC33; -.
DR STRING; 59729.ENSTGUP00000008141; -.
DR Ensembl; ENSTGUT00000008226.2; ENSTGUP00000008141.1; ENSTGUG00000007906.2.
DR GeneTree; ENSGT00720000108792; -.
DR HOGENOM; CLU_073865_0_0_1; -.
DR InParanoid; H0ZC33; -.
DR OMA; EKCHCEA; -.
DR OrthoDB; 4168067at2759; -.
DR TreeFam; TF329913; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; IEA:Ensembl.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR Gene3D; 6.20.200.20; -; 1.
DR InterPro; IPR042979; VWC2/VWC2L.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46252:SF4; BRORIN; 1.
DR PANTHER; PTHR46252; BRORIN FAMILY MEMBER; 1.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00214; VWC; 2.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..331
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003546968"
FT DOMAIN 222..280
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 44..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 331 AA; 36536 MW; CC5035611BB80373 CRC64;
MPSSTAMAIG AFSSSLLVTC CLMVALCSST VPVQKLAKAQ DKQEIKASQE KRDHTSTRDG
QTGPGKMNEI GRSGREEGSR DWKSKGSRNY SNKESWTKQK QAWNSQGTSS KSGSIQVQEQ
RDAAPEEPQV AEDSSPPASV ASVTPEPPEE YAYPDYRGKG CVDESGFVYA IGEKFAPGPS
ACPCLCTEEG PLCIQPECPR LHPRCIHVDT TQCCPQCKER KNYCEFRGKT YQTLEEFMVS
PCERCRCEAN GEVLCTVSAC PQTECVDPVY EPDQCCPICK NGPNCFAETL VIPAGREVKT
DECTICHCTY EEGTWRIERQ AMCTRHECKQ I
//
