ID H0ZCH8_TAEGU Unreviewed; 650 AA.
AC H0ZCH8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=rRNA methyltransferase 1, mitochondrial {ECO:0000256|ARBA:ARBA00034881};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008288.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008288.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008288.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR AlphaFoldDB; H0ZCH8; -.
DR STRING; 59729.ENSTGUP00000008288; -.
DR Ensembl; ENSTGUT00000008375.2; ENSTGUP00000008288.2; ENSTGUG00000008048.2.
DR GeneTree; ENSGT00390000018761; -.
DR HOGENOM; CLU_021322_4_5_1; -.
DR InParanoid; H0ZCH8; -.
DR OMA; KIAEGWE; -.
DR TreeFam; TF315167; -.
DR Proteomes; UP000007754; Chromosome 19.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0031167; P:rRNA methylation; IEA:InterPro.
DR CDD; cd18105; SpoU-like_MRM1; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR047182; MRM1.
DR InterPro; IPR047261; MRM1_MeTrfase_dom.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR46103; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46103:SF1; RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..650
FT /note="rRNA methyltransferase 1, mitochondrial"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025586575"
FT DOMAIN 388..467
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 239..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 650 AA; 68408 MW; 71AB4E79DAEB79C9 CRC64;
MLWWGQLWDA LLGTALGCSV WGQLWDVLGT ALGCSGDSSG MLCLGTALGC SVGDSSGMLC
SCSVPSPRVC PRPWLPHSWC PGSVRGLRGS PFPVPGVCTG LFPVPGVTGV PRSHSQGLSL
ECSVPVPVVC RGSLRFPISH SWGLSGALGC SVPVPCPGLR DAPFPFPGCS RSRSLSGAPG
CFFPFHCPGL WDAPFPFPFP VRGSGLLRSC SRSLSGALGC SVPVSGLFPF PVRGSGLLRS
RSRYPRPPPG GAAGRGGAAA TGAGPGPVRA PPGPVRVPPE PRRASAAERG WLSPPPARPR
APGLPAMPRA LLPRLCQRAP RLCRAGLRFR CSRGAEPGAP RGRSAPAPLP RGSRSGRELW
RAQQDSPGTG KGTERKAAVL ERTKGSEILF GLAPCGLALA RARRALFRLF LKEQRGGPGR
PLRAELGLQA AARGVPVLRV PGRALDALCR GRPHQGVCLE AAPLPLRSLR DAEEPQLGHG
ERGNRQLLWL VLEHIQDPMN LGALLRSAYF LGVDRVVATR GNSCPLTPVV SKASAGAMEV
FDVYGTDDLQ GFLKAKSAEG WEVVGTVSRP EDVEDVPVIS CSEFQWDKPV IVVIGSEGEG
LSLETQQQCQ RMLAIPPGRA LHPGLDSLNV SVAAGILLHS ICSQKRRQGD
//
