ID H0ZE22_TAEGU Unreviewed; 1457 AA.
AC H0ZE22;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=CASK interacting protein 2 {ECO:0000313|Ensembl:ENSTGUP00000008834.2};
GN Name=CASKIN2 {ECO:0000313|Ensembl:ENSTGUP00000008834.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008834.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008834.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008834.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTGUT00000008928.2; ENSTGUP00000008834.2; ENSTGUG00000026779.1.
DR GeneTree; ENSGT00940000158256; -.
DR HOGENOM; CLU_003619_1_1_1; -.
DR TreeFam; TF320582; -.
DR Proteomes; UP000007754; Chromosome 18.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF18; CASKIN-2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 27..59
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 60..92
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 93..125
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 167..199
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 199..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 260..326
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 487..550
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 556..620
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 336..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 154525 MW; E0BD03CE4D1C5352 CRC64;
MGQALFCALG ELLGSAKRLN VNYQDADGFS ALHHAALGGS LDLISLLLEA QATVDIKDSN
GMRPLHYAAW QGRVEPVRVL LRAAASVNMA SLDGQIPLHL SAQYGHYEVS EMLLQHQSNP
CLINKAKKTP LDLACEFGRL KVAQLLLNSH LCVALLEGQS KDATDPNYTT PLHLAAKNGH
KEIIRQLLKA GIEINKQTKT GTALHEAALY GKTEVVRLLL EGGVDVNIRN TYNQTALDIV
NQFTTSHASK DIKQLLREAS GILKVRALKD FWNLHDPTAL NVRAGDVITV LEQHPDGRWK
GHIHDAQKGT DRVGYFPPSI AEVISKRTGM VVPRVAPAQQ RQGPPGALPA PSGGLQHLPD
ECPHPAAPSG PAAFGHLTLT RTAPGPDSSA GDRNSVGSEG SIGSIRSAGS GQSTEGTNGQ
STSILIENAR PLPSTGDNLQ QHLLGSEPHN GTSPAGPQGL QTPGSCPPGD RVFSHQFLRP
EQLLEGKDAE AIYNWLREFQ LESYTVNFLN AGYDVPTISR MTPEDLTAIG VTKPGHRKKI
STEIGQLSIA EWLPNYIPAD LMDWLSAIGL PQYHKKLVNN GYDSITIVTD LTWEDLQEIG
INKLGHQKKI MLAVKKLRDL RKSLNQAEAT LARRKIPGSL DIVTIESLEN GECQSPHTLK
MTTFQDSELS YELQTAMSNS CHDTLGIKSS QGMSRSQESI GVRSRGSGHS QDNVLSRRLS
SPSQESLGSG ESSSSSGQSC APPRSKESPA SLPGRPSPEP FGKLMSPEGL NGFANSGGGG
GSPLKERNLP EGTDQYARPV AQKGAGTPVV TPCTPPQTPS KGTAPYVFMY PHVSLKSPTA
PSVLGAEQPK ALAHPYPSIS PGQKSSLQTS AQKGFSYLHS QCGPTEPPTT APTTGEHHNG
GEGLKHKKRS HSLNRYALSD GEHEEEEGAP SSTLGSYATL TRRPGRSQMP RGCLQAEAKV
TRSQSFAIRA KRKGPPPPPP KRLSSVSSAL TAEADAEQPP SPERQPTAPQ DVADAGATPS
DAGRGRTVKS LAAALEGTPG VSPSKPLLAP KPLHLTQDCL PRADVGEGSH DGSDASSATL
SNGSRDPFES GKPRRRTVSE PSAPMTEVAA QGEQEDACSD TEEEAKPGVS SSSSQNSSSE
CIPFAEEGNL TIKQRPKPSG HSKADAAVLD TEPGSQPAEP QGSTGKEPAA PTVTKEPPVL
EFNLTESDTV KRRPRFRERE PLQAVLKAFS MAGQAEAGGT PTPQYAQAQA VSIAGPPALA
PRPTLAGDAF DDDSVEFRIA EIEKSILSLE KGMKKAPSPT KAPSPTELVG TAVVRTPTPD
VPAKHTSVAS TKLVFSGPKT IYQQVLQPSR HTVAPWAATE VVPDVIGSLP GPGSLALETG
SKVSAKLLAA APGATLAQQR LEQTNSSLAA TLQVAEKKIT VEEAESHPGT VHSAKNILED
ISNMFDDLAD QLDAMLD
//
