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Database: UniProt
Entry: H0ZEA7_TAEGU
LinkDB: H0ZEA7_TAEGU
Original site: H0ZEA7_TAEGU 
ID   H0ZEA7_TAEGU            Unreviewed;      2293 AA.
AC   H0ZEA7;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-JUN-2019, entry version 61.
DE   RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE            EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN   Name=PLCE1 {ECO:0000313|Ensembl:ENSTGUP00000008919};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008919, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000008919, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000008919}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a
CC         1,2-diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17815,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:203600; EC=3.1.4.11;
CC         Evidence={ECO:0000256|RuleBase:RU361133};
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DR   EMBL; ABQF01027308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027310; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027315; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01027316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSTGUT00000009016; ENSTGUP00000008919; ENSTGUG00000008633.
DR   eggNOG; KOG0169; Eukaryota.
DR   eggNOG; ENOG410XPSW; LUCA.
DR   GeneTree; ENSGT00940000157356; -.
DR   InParanoid; H0ZEA7; -.
DR   OMA; IRADVHQ; -.
DR   TreeFam; TF314432; -.
DR   Proteomes; UP000007754; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR   GO; GO:0017016; F:Ras GTPase binding; IEA:Ensembl.
DR   GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
DR   GO; GO:0032835; P:glomerulus development; IEA:Ensembl.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:Ensembl.
DR   Gene3D; 2.60.40.150; -; 1.
DR   Gene3D; 3.20.20.190; -; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR028398; PLC-epsilon1.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   InterPro; IPR015359; PLC_EF-hand-like.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10336; PTHR10336; 1.
DR   PANTHER; PTHR10336:SF6; PTHR10336:SF6; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF09279; EF-hand_like; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   Pfam; PF00387; PI-PLC-Y; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00390; PHPHLIPASEC.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00148; PLCXc; 1.
DR   SMART; SM00149; PLCYc; 1.
DR   SMART; SM00314; RA; 2.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   SUPFAM; SSF54236; SSF54236; 2.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168}; Hydrolase {ECO:0000256|RuleBase:RU361133};
KW   Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Transducer {ECO:0000256|SAAS:SAAS01019513}.
FT   DOMAIN      523    776       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN     1745   1835       PI-PLC Y-box. {ECO:0000259|PROSITE:
FT                                PS50008}.
FT   DOMAIN     1862   1934       C2. {ECO:0000259|PROSITE:PS50004}.
FT   DOMAIN     2126   2229       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION      772    791       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0ZEA7}.
FT   REGION     1046   1184       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0ZEA7}.
FT   REGION     1551   1580       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0ZEA7}.
FT   REGION     1673   1710       Disordered. {ECO:0000256|MobiDB-lite:
FT                                H0ZEA7}.
FT   COMPBIAS   1046   1073       Polar. {ECO:0000256|MobiDB-lite:H0ZEA7}.
FT   COMPBIAS   1078   1115       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                H0ZEA7}.
FT   COMPBIAS   1124   1184       Polar. {ECO:0000256|MobiDB-lite:H0ZEA7}.
FT   COMPBIAS   1551   1566       Polar. {ECO:0000256|MobiDB-lite:H0ZEA7}.
SQ   SEQUENCE   2293 AA;  256508 MW;  A92D5AC665739D7C CRC64;
     MTSEEMTASV LFSVVQGKVI AAQSAGDENT ENALDTSVIR RHTASSGRQT THNLSYLHRL
     EEKSLQGSVP KIFPLAKEQL ANDKSNENFW ERNSSISDSV EFLNINCNIV QKNYKSNISC
     SQLYQSCAPL AGEEACLETG IPVSLERAML AEIQLKMNGP SLRSQTAVNK NDSSDPDKVA
     FFHLHCASER NISKALCGLH NSFILDDCLQ PVSDGDGNTT GSPACTCSIM QLTNNCENKN
     GQQLYEDALR DKYLCLERAP RKVKVACSGH SFCGSNFTGR MPSKPFLSHF EDCNDNCEEE
     LEEDFFRNKK ERSTLLIRRF CKNDKEVKKS VYTGTRAIFR TLPLGHIGTV AWNYVERRRN
     NSMKHCPSMY ELDSGVTGGS EGAPHQSQPV TPIFSTVTEE EEGAEDIFEY IPHLLRKLPT
     SVTDCIYKGD GFCVKPCVTG AYCQYRATLQ RTALSNYITG ALLEATTSLG ARSGLLNIFG
     GSTGRTMLKE RQACTSMAGS SILPSSVAGI SKELLELQHL IQFPEEVASI LTEQEQELYR
     KVLPIDYLCF LTRDLGSAEC QSKLPSLKAS ISATILSSPN GEHNAVEDLV TRFNEVSSWV
     TWLILTAGSM EEKREVFSYL VHVAKCCWNM GNYNAVMEFL AGLRSRKVLK MWQFMDQSDI
     ETMRSLKDAM AQHESSSEYR KVVNRALNIP GCKVVPFCGV FLKELCEVLD GASSLIRLCP
     RYNSQDETLE FVSDYSGQDN FLQRVGQDGL NNPEKDPTTN KFFQTIRSCT RSLESEEGED
     NVSEGSNSRK NSLKDKNCYQ FLIGDLSDSE SDIFEQLKEW DTSSTEEQQK AFCHGIELIP
     WYVLSIRADV HQFLQQGATV IHYDQDTHLS ARCFLQLQPD NSTLTWTKPT TVCPANAKAK
     LGVLGNTAEL GKYQFLGNTG LVEGFLDLFS AKAVYMGHSG IDMHTVCVQN KLCNMSLEEN
     GITLLYGLQT TDNKLLHFVA PKYTARMLYD GLLELTKAVR KMRRFPDQRL QWLRKQYVSL
     YQEDGRFEGP TLAQAVELFG GRRWSARSTG TGSLTKSTEK PNMQRNNTLG ISTAKKKKKV
     LIRGESGEAT DDEMATRKAK SCKEYRNRSG SDPQDIDEQE EPDQNIIINA SPSNNLPSRR
     AHSLTASGSP NLGATSSSPA RPVSSPVISS SKSQSSTWSS SSWHGRVKGG MKGFQNFMVS
     DSNMTFVEFV ELFKSFSVRS RKDLKDLFDV YAVPCNRSGL DPAPLYTNLK IDENSSGFQP
     DLDLLTRNVS DLGLFIKSRQ QLSDNQRQIS DAIAAASIVT NGTGVESTSL GVFGVGIQQL
     NDFLVNCQGE HCTYDEILSI IQKFEPSVNM CQQGLLSFEG FARFLMDKDN FASKNDESQE
     NIEDLQFPLS YYYIESSHNT YLTGHQLKGE SSVELYSQVL LQGCRSVELD CWDGDDGMPI
     IYHGHTLTTK ISFKEVVEAI ERNAFITSDM PVIISIENHC SLPQQRKMAE IFKNVFGDKL
     VTKFLFESDF SDDPMLPSPG QLRRKILLKN KKLKAHQTPV DILKQKAHQL AHLQAQASNG
     ASNPTPTNEE EEDEEDEYDY DYESLSDDNI LEDRPENKLS SDKLQFEYNE ENAKRLKKAD
     CATYNNKGKV YDMELGEEFY LPQNKKESRQ IAPELSDLVI YCQAVKFPGL STLNPSGSSR
     GKERKSRKSI FGNNPGRLSP GESAALAKAS GKGPFDAMRQ TWEDPCSPYN SPASLSAIIR
     TPKCYHISSL NENAAKRLCR RYSQKLIQHT TCQLLRTYPA ATRIDSSNPH PLIFWLHGVQ
     LVALNYQTDD LPLQLNAAMF EANGGCGYVL KPPVLWDKNC SMYQHFCPLE RDLDNKEPAI
     YSLTIVSGQN VCPSNSTGSP CIEIDVLGMP LDSCHFRTKP IHRNTLNPMW NEQFLFRVHF
     EDLVFLRFAV VENNCSAVTA QRIIPLKALK RGYRHVQLHN LHNETLEISS LFINSRRMEE
     SPSGNSLPAS MLFSQGERKA AVTYKVTVHG IPGPEPFTVF SVSAGTTAAQ LLHQILATIK
     GTESCAADYF LMEEKSFISK EKSECRKPPF QRVIGPEEGL VQLLNSWFPE EGYVGRIIFK
     TREENLNERN VFQEAKEEAA ISSEDDSFFV QVHDVSPEQP RTVIKAPRLS TAQDVIQQTL
     CKAKYSYSIL SNPNPSDYVL LEEVTKEPAN KKSSTSKPSQ RILSDQECVF QAQSKWKGAG
     KFILKLKEQV QAARDDKRKG ISFTSELKKL TKSSKQYRGF VSPALQGLSD GAQGREERAA
     CAVAFSDTME YKD
//
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