ID H0ZED0_TAEGU Unreviewed; 1827 AA.
AC H0ZED0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Myosin XVI {ECO:0000313|Ensembl:ENSTGUP00000008942.2};
GN Name=MYO16 {ECO:0000313|Ensembl:ENSTGUP00000008942.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000008942.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000008942.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000008942.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 59729.ENSTGUP00000028597; -.
DR Ensembl; ENSTGUT00000009039.2; ENSTGUP00000008942.2; ENSTGUG00000008643.2.
DR GeneTree; ENSGT00940000158920; -.
DR HOGENOM; CLU_002267_0_0_1; -.
DR TreeFam; TF332267; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14878; MYSc_Myo16; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036042; MYSc_Myo16.
DR InterPro; IPR029353; NYAP_C.
DR InterPro; IPR039482; NYAP_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47335; UNCONVENTIONAL MYOSIN-XVI; 1.
DR PANTHER; PTHR47335:SF1; UNCONVENTIONAL MYOSIN-XVI; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF15452; NYAP_C; 1.
DR Pfam; PF15439; NYAP_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT REPEAT 92..124
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 125..157
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 221..253
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 254..286
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 401..1145
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1024..1046
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1211..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1651..1827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1566..1586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1606..1627
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1651..1679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1733..1749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 497..504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1827 AA; 203052 MW; 76E6347637761E83 CRC64;
MEIEQCLLES LPLGQRQRLV KRMRCDQIKA YYEREKAFQK REGYGKKLKH GKNQRVCFNL
ADMIQDAIIR HDDKEVLRLL KDGADPHMLL SSGGSLLHLC ARYDNAFAAE ILIDRGVNVN
HQDEDFWTSM HIACACDNPD IVLLLLLAGA NVLLQDVNGN IALDYAVEGT ESSSILLMYL
EENGVELNSL RQMKIQRAMT MLTDVRQLIS SGGSVNQKNE EGVTLLHVAC ANGYKNVASL
ILDHGADLNV VDNQYWTPLH LAAKYGQTNL VKLLLMHQAN PNLLNCNNEK PSDVAASDFI
EEMLLKAEIV WEEKMKDPLA VSTLSQEEPY EEIMHDLPTI SNKLNPLALP IAKQDSLLEK
DTMFKDAAKG LCKQQSQDSA SENITVNTTT KLEQIKLMPP APNDDLASLS ELTDSSLLYE
IQKRFNNNQI YTYIGDILLL VNPFKELPIY STMVTQLYLS NSGKLCSSLP PHIFSCAERA
YHMLFQEQRP QCFILSGESG SGKTEACKQI VKHLTCRANC SRNTFDTKIK HVNCILEAFG
HAKTPLNFFS SCFIKYFELQ FCERKKTLIA ARIYTYMLEK SRVVIQPLNQ SNFHVFYLMM
DGLSAEEKYT LYLSNLSAHR YLSQTVSEET MLAANPQNRE KLTILKQALG ALGFNSLEVE
NLFVILSAIL HLGDIRFTSL TDAETAFVSD LQLLEQVAGM LQVSPDELAS ALTTDVQYFK
GDTIVRRHTI EMADFYRDLL AKSLYGRLFS FLVNTINCYL QNQDESGSDQ VFEIGVLDIF
GFEEFQKNTF EQLCVNMTNE KIHQYINEVL FLQEEAECVQ EGVAMETMYS PGNHTAVLDF
FFQKPSGFLS MLDEESQSVW SVEQGLSKRI QSYLDTSDTN TVYSSTKDGN GNLAPKDLGS
TFTVMHYAGR VTYEIAGAIE KNKDSLSQNL IFVMKTSENV VINQLFQSKL TQTGSLVPPY
HSLKIKGCKA ALLSKKSSVT CASGEAKKYI ELSKLLKKKG TSSFLQRLER GGPTTVAIQL
RKSLADIIGK LQNCTPHLVH CIKPNNSKLP DTFDNFYVSA QLQYIRVLDM VKIIRHGYPV
RLSFTDFLSR YKDLADTAAG EKKKLSAKER CHLVLQQCKL QGWQIGVRKV FLKYWQADHL
NDLCLQLQKK IITCQKVVRG FLARRHLLQK RSIKQQEVTS IKSFLQNAED MGLKTYDDLV
IQNASDIARE NDRLRNEMNG AYHRDKGEAR SRPEEGQKRA EDKGGKVSED SFAGCRTSKH
FHSSSVPVPM AVDGLVHSAA GSSIRSPSLH SVFSMDDSNS LPSPRKQPPP KPKRDPNTRL
SASYEAVSAC LSAASKETAN EVLTRPRPHS DDYSTMKKIP PRKPKRSPNT KLSGSYEEIP
GQKPGNVKKA STVVKPGVYD TVTVQRTAST DGPQHGVLNL FMSQGEEENE PVYIEMVGNA
VKNSSVEAES PEQGESVYEE MKYFLPEEGS NGNRIIPVVT GSPPLLFESK KNVNIEDGTL
DGNSQAALIY RDSCDIPAPF PNLLPHRPPL LVFPPTPVTC SPASDESPLT PLEVKKLPVL
ETNLKYPVQS EGSSPLSPQY SKGQKGENER PVSPGLIVFS VSTKVTPPST PPPTLPPPPP
PVPPPASYRA STHFASPPET CATFLINAGK TGTNSDLSKV PQRTNPAQLG CSSSPFSKLP
YSPKLARADH RKLNSNSSSS FAYNPTNSRS LTSPLDELTS LFNSGRSVLR KSAAGRKIRE
PEGAETNLNL RSREDPNTPD PGSETQDKNA NNHGTQSSNP LSSSVTAENG NSVSNGLPEE
NDFSRLSAST TAGSSIQRHR ESHTSQE
//
