ID H0ZF49_TAEGU Unreviewed; 1410 AA.
AC H0ZF49;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Zinc finger FYVE domain-containing protein {ECO:0000256|PIRNR:PIRNR037289};
GN Name=ZFYVE9 {ECO:0000313|Ensembl:ENSTGUP00000009211.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000009211.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000009211.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000009211.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037289}. Early
CC endosome membrane {ECO:0000256|PIRNR:PIRNR037289}.
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DR STRING; 59729.ENSTGUP00000009211; -.
DR Ensembl; ENSTGUT00000009310.2; ENSTGUP00000009211.2; ENSTGUG00000008916.2.
DR GeneTree; ENSGT00940000154290; -.
DR HOGENOM; CLU_004326_1_0_1; -.
DR InParanoid; H0ZF49; -.
DR OMA; IPPNCGG; -.
DR OrthoDB; 3061552at2759; -.
DR TreeFam; TF324904; -.
DR Proteomes; UP000007754; Chromosome 8.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-UniRule.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd15729; FYVE_endofin; 1.
DR Gene3D; 3.30.500.40; -; 1.
DR Gene3D; 3.30.1360.220; Domain of unknown function (DUF3480), N-terminal subdomain; 1.
DR Gene3D; 4.10.720.10; Smad anchor for receptor activation, Smad-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR022557; SARA-like_C.
DR InterPro; IPR024608; SARA-like_SBD.
DR InterPro; IPR035438; SARA/endofin.
DR InterPro; IPR037145; SARA_Smad-bd_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46319; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46319:SF2; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 9; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF11409; SARA; 1.
DR Pfam; PF11979; SARA_C; 1.
DR PIRSF; PIRSF037289; SARA/endofin; 2.
DR SMART; SM01421; DUF3480; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM01422; SARA; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037289};
KW Endosome {ECO:0000256|PIRNR:PIRNR037289};
KW Membrane {ECO:0000256|PIRNR:PIRNR037289};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR037289};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 683..742
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 404..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1410 AA; 153396 MW; D67A27EEE39FE968 CRC64;
MENYFQAEAY NLDKVLDEFE QNEDAAVSPT LLGAKWNQIL DPPSRRLSFN SAVASVNEAA
TPSECQQRLK SCSLSHSVTT LTGGGDLCAN GKDFSISPET PVMWIDDQAA ADDQLIKRNS
NRDDQCYSME AGEKKCGNTA CLPEEKNVLV VAVMHNCDRT LQSGDVVDCT SYSSQSLMDS
ISFTLDNENR QSDQFSVTVN GSTEKDIDTE KQVDRLCTED ESVSHLINAS SESLTAACPS
SRLKEDFNMN KDLLFSEATT AGINAVTLLQ RPVDGTAKMQ ESCASLENFT SKAIPQRTDL
EAKNSSGSSS GSLIVEQETT QQLQSRLSGL TETCQPNVAG SGNYKECVAE DVGAAEGKVI
ECDKNLGTTE LHSMAECYPE SQEMTNWELT KLNEVNNKQT LGENERLLQT KQPDDASENS
KEDEDGVLEV GIDLKGSGTD ELGGSSLSDV MATSAASSLS NCCDSYGMQN PVVAHVPKTL
PSKEDSVTEE KEIEESKSEC YTNVYEQRGN DATEGSGLIL NSTGDHIKKN YLHNLCSQVS
SMQGQTSPKP VTNLQYISVP FGGARPKQPT NLKLQIPKPL SDHLQNDVIP PNCGGNSKNK
NVFGKTQSGD TADTFPGETS SNASGTGSNG EHLDEYESGV SNSSCLAVAP DSPDNDLRAG
QFGAPARKPF TTLGEVAPVW VPDSQAPNCM KCEARFTFTK RRHHCRACGK VFCAACCSLK
CKLLYMDRKE ARVCVICHSV LMNAQAWENM MSASSQSPNP NNPAEYCSTI PPLQQAQASG
ALSSPPPTVM VPVGVLKHPG AEVAQPREQR RVWFADGILP NGEVADAAKL TVAGTTSTGT
LAVSHDPSKP MANNTSSAET DNASVFSGNI TQVGSPVGSA MNLIPEDGLP PILISTGVKG
DYAVEERPSQ ISVMQQLEDG GPDPLVFVLN ANLLSMVKIV NYVNRKCWCF TTKGMHAVGQ
SEIVILLQCL PDEKCLPKDI FNHFVQLYRD ALAGNIVGNL GHSFFSQSFL GSKEHGGFLY
VAATYQSLQD LVLPTPPYLF GILIQKWETP WAKVFPIRLM LRLGAEYRLY PCPLFSVRFR
KPLFGETGHT IMNLLADFRN YQYTLPVVQG LVVDMEVRKT SIKIPSNRYN EMMKAMNKSN
EHVLAGGACF NEKADSHLVC VQNDDGNYQT QAISIHNQPR KVTGASFFVF SGALKSSSGF
LAKSSIVEDG VMVQITAENM DSLRQALREM KDFTITCGKV DAEDPQEHVH IQWVEDDKNF
NKGVVSPIDG KSMESITSVK IFHGSEYKAN GKVIRWTEVF FLENDEQHNG LSDPADHSRL
TENVAKAFCL ALCPHLKLLK EDGMTKLGLR VTLDSDQVGY QAGSNGQPLP CQYMNDLDSA
LVPVIHGGAC QLSEGPVIME LIFYILENIS
//
