ID H0ZFU6_TAEGU Unreviewed; 926 AA.
AC H0ZFU6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL6 {ECO:0000313|Ensembl:ENSTGUP00000009458.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000009458.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000009458.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000009458.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; H0ZFU6; -.
DR STRING; 59729.ENSTGUP00000038308; -.
DR Ensembl; ENSTGUT00000009559.2; ENSTGUP00000009458.2; ENSTGUG00000009140.2.
DR GeneTree; ENSGT00940000156791; -.
DR HOGENOM; CLU_007105_4_1_1; -.
DR TreeFam; TF320922; -.
DR Proteomes; UP000007754; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 87..182
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 412..439
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 104993 MW; 8EE02D6D82748FA2 CRC64;
MSSEEKSISP AHKTSTPSHR SASSSSSSQR DRRQSVHILE RKASSGSTDP SLSKQFLDSD
HLSLSKEPDS WEIIEGLKIG QTNVQKPDKH EGFMLKKRKW PLKGWHKRFF VLDNGMLKYS
KSPIDIQKGK VHGSIDVGLS VMSIKKKARR IDLDTEEHIY HLKVKSQDSF DAWVSKLRHH
RLYRQNEIVR SPRDASFHIF PSASTTESSP AANVSDGKVQ QNNFPWQPPI PCSNSLPVTC
TTGQSKVAAW LQDSEEMDRC AEDLAHCQSN LVELSKLLQN LEILQRTQSA PNFTDMQEGP
APKGQFSTTR RRQRLAAAVA TTVPFSATMS PVRLHSSNPN LCADIEFQAP PSHVTDPLEC
STEYMKLQEE FCLMAQKVHS LLKSAFNSIA IEKEKLKQIV SEQDLTGHNA QIAHLRQSLS
QALNQNAELR SRLNRIHSES VICDQVVSVN IIPSPDETGE QIHVSLPLSQ QVSNESRLSM
SESVSEFFDA QEVLLSASSS ENEASDDESY ISDVSDNISE DNTSVADNIS RQILNGELTG
GAFRNGRRTC LPAPSPDTSN INLWNILRNN IGKDLSKVSM PVELNEPLNT LQHLCEELEY
SELLDKAAET DDPYERMVLI AAFAASGYAS TYFRAGSKPF NPVLGETYEC IREDKGFRFF
SEQVSHHPPI SACHCESKNF VFWQDIRWKN KFWGKSMEIL PVGTLNVTLP KYGDYYVWNK
VTTCIHNILS GRRWIEHYGE ITIRNTKSSV CICKLTFVKV NYWNSNVNEV QGVVIDQEGK
VVHRLFGKWH EGLYCGVAPS AKCIWRPGSM PTNYERYYGF TRFAIELNEL DPLLKDLLPA
TDARFRPDQR LLEEGNIEAA ASEKQRIEEL QRARRRYMEE NGIEYVPKFF KKVIDANQRE
AWVTNETYWE LRKDPGFSKV DIPVLW
//
