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Database: UniProt
Entry: H0ZJ48_TAEGU
LinkDB: H0ZJ48_TAEGU
Original site: H0ZJ48_TAEGU 
ID   H0ZJ48_TAEGU            Unreviewed;      2746 AA.
AC   H0ZJ48;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   13-FEB-2019, entry version 61.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSTGUP00000010616};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSTGUP00000010616};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010616, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000010616, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000010616}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
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DR   EMBL; ABQF01046346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01046355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 59729.ENSTGUP00000010616; -.
DR   Ensembl; ENSTGUT00000010728; ENSTGUP00000010616; ENSTGUG00000010241.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   InParanoid; H0ZJ48; -.
DR   OMA; PRHAPYK; -.
DR   TreeFam; TF312815; -.
DR   Reactome; R-TGU-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-TGU-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-TGU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-TGU-418457; cGMP effects.
DR   Reactome; R-TGU-5578775; Ion homeostasis.
DR   Reactome; R-TGU-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000007754; Chromosome 12.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2272   2294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2306   2324       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2330   2356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2392   2417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2438   2460       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2568   2591       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    371       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    433       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1589   1609       {ECO:0000256|SAM:Coils}.
FT   COILED     2704   2724       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2746 AA;  312484 MW;  1663EA64A75CEB16 CRC64;
     MTDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
     CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
     IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
     KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
     RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
     SLFRFKHLAT GHYLAAEVNP DYEEDDLECQ SSLDPEQEAR RGRGPQEKMA YSLVSVPEGN
     DISSIFELDP TTLRGGDSLV PRNSYVRLRH LCTNTWVHST NIPIDKEEEK PVMLKIGTSP
     VKEDKEAFAI VPVSPAEVRD LDFANDASKV LGSIAGKLEK GTITQNERRS VTKLLEDLVY
     FVTGGTNSGQ DVLEVVFSKP NRERQKLMRE QNILKQIFKL LQAPFTDSGD GPMLRLEELG
     DQRHAPFRHI CRLCYRVLRH SQQDYRKNQE YIAKQFGFMQ KQIGYDVLAE DTITALLHNN
     RKLLEKHITA AEIDTFVSLV RKNREPRFLD YLSDLCVSMN KSIPVTQELI CKAVLNPANA
     DILIETKLVL SRFEFEEVSS GENALEVGED EEEVWLFWRD SNKEIRSKSI RELAQDAKEG
     QKEDRDVLSY YSSELSRAAW VSWGGKLLFQ AQNSLQRGRV KSLRRAESTK LFVVRSPGID
     MSQCKLIFKE YPVYLHAKFC FVFFSVLFFF FPLFSYDSSG TSKDEIKERF AQTMEFVEEY
     LRDVVCQRFP FSDKEKNKLT FEVVNLARNL IYFGFYNFCD LLRLTKILLA ILDCVHITTI
     FPITKMAKGE ESKGSNVMRS IHGVGELMTQ VVLRGGGFLP MTPLAAAPEG NVKQSEPEKE
     DILVMDTKLK IIEILQFILN VRLDYRISCL LCIFKHEFDE SNAQMSESPT GSSSQEMPAN
     VPGALDFEHI EEQAEGIFGG RKENTPLDLD DHGGRTFLRV LLHLTMHDYP PLVSGALQLL
     FRHFSQRQEV LQAFKQVPVW IASEAGRMPV ADQVLPTFPD SSPMTELWVY KGQGPDEAMD
     SVPGENEHKK KEEGHSKSQK PESTSSYNYR VVKEILLRLS KLCVQEGASV RKSRKQQQRL
     LRNMGAHAVV LELLQIPYEK AEDTRMQEIM KLAHEFLQNF CAGNQQNQAL LHKHINLFLN
     PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT IVKAEGKFIK
     KCQDMVMAEL VNAGEDVLVF YNDRASFQTL VQMMRSERDR MDENSPLMYH IHLVELLAVC
     TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE VEMKEIYTSN
     HMWKLFENFL VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF SDQSTTLQTR
     QPVFVQLLQG VFRVYHCTWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL DSQVNNLFLK
     SHNIVQKTAM NWRMTARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL RPLVQAELSV
     LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV LQTLREMMTK
     DRGYGEKSVN SNYSHNSFLP QAPETESPVE QELDQTLPQR QLEDHRRGEA LRQVLVNRYY
     GNVRAAGRRE SLTAFGNGPL SAGSPGKAGP GGGSSGSSSM SRGEMSLADV QCHLDKEGAS
     NLVIDLIMNA TSDRVFHESI LLAIALLEGG NTTIQHSFFC RLTEDKKSEK FFKVFYDRMK
     VAQQEIKATV TVNTSDLGNK KKDEDSDRDV PNRKRVREPM SQITEEVRDQ LLEASAATRK
     AYNAYRREAD PEEHYSAGEG AQAAADKSKD ELEMSAVISI MQPILRFLQL LCENHNRDLQ
     NFLRCQNNKT NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ TLESLTEYCQ
     GPCHENQNCI ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKAMNNAS KLLLAIMESR
     HDSENAERIL YNMRPKELVE VIKKAYLQGE VEFEDGENGE DVAASPRNVG HNIYILAHQL
     ARHNKELQNM LKPGGQIEGD EALEFYAKHT AQIEIVRSDR TMEQIVFPVP SICEFLTKES
     KLRIYYTTER DEQGSKINDF FLKSEDLFNE MNWQKKLRAQ PFLYWCARNM SFWSSISFNL
     AVLMNLLVAF FYPFKGIRGG TLEPHLSGLL WTAMLISLAI VIALPKPHGI RALIASTILR
     LIFSVGLQPT LFLLGAFNVC NKIIFLMSFV GNCGTFTRGY KAMIMDVEFL YHLLYLLICA
     LGLFVHEFFY SLLLFDLVYR EETLLNVIKS VTRNGRSIIL TAVLALILVY LFSIVGYLFF
     KDDFILEVDK LPNETLLPEP GETMTGEFLY SDVCKAGSSD NCSSIIPSDQ LITEEMEEEN
     KEHTCETLLM CIVTVLSHGL RSGGGVGDVL RKPSKEEPLF AARVIYDLLF FFMVIIIVLN
     LIFGVIIDTF ADLRSEKQKK EEILKTTCFI CGLERDKFDN KTVTFEEHIK EEHNMWHYLC
     FIVLVKVKDS TEYTGPESYV AEMIKVKRNL DWFPRMRAMS LVSSDSEGEQ ELRILEKLES
     TMKLVTLSGQ LSELKDQMTE QRKQKQRIGL LGHPPPMNVN LQQQPA
//
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