ID H0ZJT6_TAEGU Unreviewed; 926 AA.
AC H0ZJT6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Zinc finger FYVE-type containing 28 {ECO:0000313|Ensembl:ENSTGUP00000010855.2};
GN Name=ZFYVE28 {ECO:0000313|Ensembl:ENSTGUP00000010855.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000010855.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000010855.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000010855.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the lst-2 family.
CC {ECO:0000256|ARBA:ARBA00008755}.
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DR AlphaFoldDB; H0ZJT6; -.
DR STRING; 59729.ENSTGUP00000010855; -.
DR Ensembl; ENSTGUT00000010968.2; ENSTGUP00000010855.2; ENSTGUG00000010524.2.
DR GeneTree; ENSGT00940000157217; -.
DR HOGENOM; CLU_007360_1_0_1; -.
DR InParanoid; H0ZJT6; -.
DR OMA; PELGYDR; -.
DR TreeFam; TF320752; -.
DR Proteomes; UP000007754; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR GO; GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd15731; FYVE_LST2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043269; FYVE_LST2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46465; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR PANTHER; PTHR46465:SF2; LATERAL SIGNALING TARGET PROTEIN 2 HOMOLOG; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 856..912
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 358..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 103585 MW; E879D5D109A5DE11 CRC64;
MMNRFRKWLY KPKRTDPQLL AQFYYADEEL NQVAAELDSL DGRKDPQRCT LLVNQFRSCQ
DNVLNIINQI MDECIPHERA NRDFCVKFPE EIRHDNLAGQ LWFGAECLAA GSIIMNREIE
SMAMRPLAKD LTRSLEEVRN IIRDQALRDL NLYTEKMKDS LKHFDVLFAE FELSYVSAMV
PVKSPKEYYV QQEVIVLFCE TVERALRLGY LTQDMIDDYE PALMFTIPRL AIVCGLVVYS
EGPLNLDHKP EDMSELFRPF HTLLRKIRDL LQTLTEDELH TLERNLCISQ DVDFPVRADP
EVPSVIAPGI TATLPPKELS AKAENTEAEL ACSMQYDEQE LEQLNRMVHR VGDEMSSLLS
PPSICQSPAH RPSLRNSSST EASPTRHHLD NLTDEEDRVF FMDDLDGAGE ALAGLDSVSD
TFAWVNNPCH DSKQNLQYRD ALLYENGHQT EETLLLKDAE SVLSNNNNVE DGKQMSGISV
PNSCSCLEGP DSQLYLNGWD AYADDAETAE VIAHRTGGMK ISATVIFNPK SPSSSESPVT
TPEAAISCIP GSANPLANEE EDESHKLSIA ATNCLINSCV CCGSCEDSRE DGVEGLKTKH
SAGGVVNASY TLVKSKEMDH VDNLDSSVPE QETLKPETSA LLAERDFGSE EQKLPISSKC
LAHSSGSQVG VESDSQGEAE SISNQQKKWE KRKQLCDKKM DYNEDASSER TAKEDVKSRS
SSSSLMTSSC SSDDIDQEEI QLALQAAKIA TREKIRSRFH GSNDLIHRLF VCISGVADQL
QTNYASDLRS ILKTLFEVMA TKPETEDKEK QKKVNHGLRN AALEDCALCQ ESISSSELAA
KARDGDFEDP PDWVPDEACS YCTACKAPFT VIRRKHHCRS CGKIFCSRCS SHSAPLPRYG
QMKPVRVCTH CYMFHVTPFY SDRAGI
//
