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Database: UniProt
Entry: H0ZKL5_TAEGU
LinkDB: H0ZKL5_TAEGU
Original site: H0ZKL5_TAEGU 
ID   H0ZKL5_TAEGU            Unreviewed;      1171 AA.
AC   H0ZKL5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=STAT1 {ECO:0000313|Ensembl:ENSTGUP00000011136};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011136, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000011136, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000011136}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; ABQF01010007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01010008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABQF01010009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSTGUT00000011256; ENSTGUP00000011136; ENSTGUG00000010768.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   InParanoid; H0ZKL5; -.
DR   OMA; PLWIDGC; -.
DR   TreeFam; TF318648; -.
DR   Proteomes; UP000007754; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd10372; SH2_STAT1; 1.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 1.10.8.1200; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 2.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR038295; STAT1_C_sf.
DR   InterPro; IPR035859; STAT1_SH2.
DR   InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 2.
DR   Pfam; PF00017; SH2; 2.
DR   Pfam; PF12162; STAT1_TAZ2bind; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 2.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 2.
DR   SUPFAM; SSF55550; SSF55550; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      232    334       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      994   1091       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      603    647       {ECO:0000256|SAM:Coils}.
FT   COILED      730    754       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1171 AA;  134949 MW;  0C82D00DF6E8CA69 CRC64;
     LTYDGDPIPV QRPQLLEKVN FLLYNLFRKL LIKLPELNYQ IRVKATIDNN RRFVLCGTHV
     KAMNMDESAN GSLSVEFRHL GPHMVTEELH SISFETQVCL YGLTINLETS SLPVVMISNV
     SQLPNAWASI IWYNLSTNDP QNLSFFNNPP AATLSQLLEV LSWQFSSYVG RGLNSEQLNM
     LAEKLVGKFS YNDYQLSWAK FCKEHLPGKS FTFWVWLEAI LDLIKKHILP LWIDGYVMGF
     VSKEKERILL KDKTPGTFLL RFSESNLGGI TFTWVDQLEN GDVTFHSVEP YNKGRLSALP
     FADILRDYKV IMADNVPENP LKYLYPDIPK DKAFGKHYSC QPNEGRGSIS LLTLPAQQLQ
     TSFCKYISKF CPYATMNLLR FCHEDLPPPS EGRGTDYPGV PQQSPDFSIP LFAGSQHQTK
     PRRATLDRET ATRMDTIPAS RAWVQSEYYY NIYTDFFFTP SRMSQWYQLQ QLDSKFLEQV
     HQLYDDSFPM EIRQYLAQWL ENQDWEHAAN NVSFATLLFH DLLSQLDDQF SRFLIENNFL
     LQHNIRKSKR NLQDNFQEDP IHMAMIIHNC LKEERKILSC AKACNEMEVG SVQNTATGMP
     DKQKELDTNI RTLKSDVNDV EQDIKALENL QDEYDFKCKT LQNREHESSS MSQEEYKKEQ
     LNLQHMFLSL DHRRKDVVSA IVKLLQSTEQ VQAALINDEL VEWKHRQQTA CIGGPPNACL
     DQLQNWFTIV AESLQQVRQQ LKKLEELEQK FTYDPDPITK NKQFLQDLTN KLFQQLIQRL
     LVKLQELNYN LKVKVLFDKD VTEKNSVKGY VASEFNFSFS LCRFRKFNIL GTNTKVMNME
     ESTNGSLAAE FRHLQLKEQK NTGSRTNETT SLPIVVISNV SQLPSGWASI LWFNMLSTDP
     KNLSFFLNPP SAKWSKLADV LSWQFSSVTK RGLNADQLSM LGEKLLGPSN GGSQDGLIPW
     TRFCKENIND KNFPFWLWIE GILELIKKHL LCLWNDGCIV GFISKERERA LLKDQSPGTF
     LLRFSESSRE GAITFTWVEE SQNGKEPLFH SVEPYTKKEL SAVTFPDIIR NYKVMAAENI
     PENPLRFLYP NIPKDNAFGK YYSRPKEAPE PMDLDGPKGN GYIKTELISV SEVHPSRLQS
     PENLLPMSPE EFDEVSRMVG PAEIDTVVRT R
//
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