ID H0ZLF9_TAEGU Unreviewed; 330 AA.
AC H0ZLF9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=CDK2 associated cullin domain 1 {ECO:0000313|Ensembl:ENSTGUP00000011432.2};
GN Name=CACUL1 {ECO:0000313|Ensembl:ENSTGUP00000011432.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011432.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011432.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011432.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019}.
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DR AlphaFoldDB; H0ZLF9; -.
DR STRING; 59729.ENSTGUP00000011432; -.
DR Ensembl; ENSTGUT00000011556.2; ENSTGUP00000011432.2; ENSTGUG00000011089.2.
DR GeneTree; ENSGT00390000000403; -.
DR HOGENOM; CLU_062250_1_0_1; -.
DR InParanoid; H0ZLF9; -.
DR OMA; PFWINPS; -.
DR OrthoDB; 2938756at2759; -.
DR TreeFam; TF329263; -.
DR Proteomes; UP000007754; Chromosome 6.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR InterPro; IPR042652; CACUL1.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR46636; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46636:SF1; CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00888; Cullin; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 98..254
FT /note="Cullin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00888"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 330 AA; 36797 MW; 5E3413E5796B82D7 CRC64;
MEEESMEEEG GGEAMMDDQN HNNWGAGGYG RLLLGERALP ARPAGPEQNG AGLRGCEPGA
AAGRAGAAGA IAAINISAST SKFLMNVITI EDYKSTYWPK LDSAIDQLLT QSPGDYIPIS
YEQIYSCVYK CVCQQHSEQM YSDLIKKITN HLERVSKELQ ASPPDLYIER FNVALGQYMG
ALQSIVPLFI YMNKFYIETK LNRDLKDDLI KLFTEHVAEK HIYNLMPLLL EAQSTPFQIT
PSTMANIVKG LYTLRPEWVQ MAPALFSKFI PNILPPAVES ELQEYAAQDQ KLQRELIQNG
FTRGDQSRKR AGEELTYNGS STCASSRGYR
//
