ID H0ZLG4_TAEGU Unreviewed; 469 AA.
AC H0ZLG4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Calcitonin gene-related peptide type 1 receptor {ECO:0000256|ARBA:ARBA00015885, ECO:0000256|RuleBase:RU368099};
DE Short=CGRP type 1 receptor {ECO:0000256|RuleBase:RU368099};
DE AltName: Full=Calcitonin receptor-like receptor {ECO:0000256|ARBA:ARBA00030562, ECO:0000256|RuleBase:RU368099};
GN Name=CALCRL {ECO:0000313|Ensembl:ENSTGUP00000011437.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011437.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011437.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011437.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for calcitonin-gene-related peptide (CGRP). Receptor
CC specificity may be modulated by accessory proteins. The activity of
CC this receptor is mediated by G proteins which activate adenylyl
CC cyclase. {ECO:0000256|RuleBase:RU368099}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU368099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368099}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314, ECO:0000256|RuleBase:RU368099}.
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DR AlphaFoldDB; H0ZLG4; -.
DR STRING; 59729.ENSTGUP00000011437; -.
DR Ensembl; ENSTGUT00000011561.2; ENSTGUP00000011437.2; ENSTGUG00000011077.2.
DR GeneTree; ENSGT00940000159898; -.
DR HOGENOM; CLU_002753_4_2_1; -.
DR InParanoid; H0ZLG4; -.
DR OMA; AIVICIY; -.
DR OrthoDB; 5345963at2759; -.
DR TreeFam; TF315710; -.
DR Proteomes; UP000007754; Chromosome 7.
DR GO; GO:1903143; C:adrenomedullin receptor complex; IEA:Ensembl.
DR GO; GO:1990406; C:CGRP receptor complex; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:1990409; F:adrenomedullin binding; IEA:Ensembl.
DR GO; GO:0001605; F:adrenomedullin receptor activity; IEA:Ensembl.
DR GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; IEA:Ensembl.
DR GO; GO:0004948; F:calcitonin receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1990410; P:adrenomedullin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProtKB-UniRule.
DR GO; GO:0071329; P:cellular response to sucrose stimulus; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR GO; GO:1990874; P:vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR CDD; cd15274; 7tmB1_calcitonin_R; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR003289; GPCR_2_CGRP1_rcpt.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF21; CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR01351; CGRPRECEPTOR.
DR PRINTS; PR01350; CTRFAMILY.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU368099};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU368099};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU368099};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU368099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368099};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368099};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Signal {ECO:0000256|RuleBase:RU368099, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU368099};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368099}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..469
FT /note="Calcitonin gene-related peptide type 1 receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025470839"
FT TRANSMEM 147..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 224..253
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 260..283
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 295..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368099"
FT DOMAIN 53..137
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 147..394
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 469 AA; 53961 MW; C29C2F3A4A08BD51 CRC64;
MKMTKIWITF LLLFLLVTMF FATASPAEGH QNSTMDLAQL SVTRNKIMTA QYECYQKIMQ
DPIHKKEGPY CNRTWDGWLC WSDVAAGTVS VQRCPDYFQD FNPSEKVTKI CDPNGNWFRH
PESNRTWTNY TQCNIYTHEK VKTALNLYYL AIIGHGLSIA SLLISLGIFF YFKSLSCQRI
TLHKNLFFSF VCNSVVTIIS LTAVANNQEL VATNPVSCKV SQFIYLYLMG CNYFWMLCEG
IYLHTLIVVA VFAEKQHLMW YYLLGWGFPL IPACIHAVAR SLYYNDNCWI SSDTHLLYII
HGPICAALLV NLFFLLNIVR VLITKLKDTH KAESNLYMKA VRATLILVPL LGIEFVLFPW
RPEGQIAEEV YDYVMHILMH YQGLLVATIF CFFNGEVQAV LRRHWNQYKI QFEHSFSHSD
AMRTASYTVS TISDVQGYGY GHDCAGEHLN GKGYHDMDSV ALKTEKLYG
//
