ID H0ZLT4_TAEGU Unreviewed; 438 AA.
AC H0ZLT4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=G protein-coupled receptor 180 {ECO:0000313|Ensembl:ENSTGUP00000011557.2};
GN Name=GPR180 {ECO:0000313|Ensembl:ENSTGUP00000011557.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011557.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011557.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011557.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; H0ZLT4; -.
DR Ensembl; ENSTGUT00000011682.2; ENSTGUP00000011557.2; ENSTGUG00000011209.2.
DR GeneTree; ENSGT00940000153981; -.
DR HOGENOM; CLU_040652_0_0_1; -.
DR InParanoid; H0ZLT4; -.
DR OMA; DHSCTEK; -.
DR OrthoDB; 5391031at2759; -.
DR TreeFam; TF314975; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..438
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025379352"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 141..403
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 438 AA; 49428 MW; AE8081FFACA4B7BB CRC64;
MRWRLLLLLS AAAGCCWGLA AGKTLRGGFA SAAARREPWR PVARFQFHGD HALLCVRIKN
TAVAVAKAAR LHLFQGQEWQ KLENSVQDHS CTEKFSKAQL TMTVNHTEQN LTVSQIPYPE
TWYVFYVDKF TCEENYSESE DIQFEMVLLN PDAEGNPLDH FSAGESGLHE FFFLLVLVYF
ITACIYAQSL WQTIRKRGPM HGVLKVLTIA LLLQAGSAFA NYLHFSSYSR DGIGAPFMGS
LAELCDIVSQ IQMLYLLLSL CMGWTIGRMK KSHGRPLQWD SSPASTGIAV VVVVTQSILL
IWEQFEDTNH HSYHSHHGLA SGLLIGLRVC LALSLAAGLY QIITVERSTL KREFYITFAK
ACILWFLCHP CLATITVIFR EYQREKIITI GVILCQCISM VILYRLFLSH SLYWEVSSLS
SVTLPLTISS GHKNRHHF
//
