ID H0ZLV2_TAEGU Unreviewed; 1263 AA.
AC H0ZLV2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Papilin, proteoglycan like sulfated glycoprotein {ECO:0000313|Ensembl:ENSTGUP00000011575.2};
GN Name=PAPLN {ECO:0000313|Ensembl:ENSTGUP00000011575.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011575.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011575.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011575.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0ZLV2; -.
DR Ensembl; ENSTGUT00000011700.2; ENSTGUP00000011575.2; ENSTGUG00000011230.2.
DR GeneTree; ENSGT00940000156891; -.
DR HOGENOM; CLU_423662_0_0_1; -.
DR Proteomes; UP000007754; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd22635; Kunitz_papilin; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF179; PAPILIN; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 768..818
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 897..987
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1044..1114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1115..1204
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1214..1253
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 621..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 35..71
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 39..76
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 50..61
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 1263 AA; 139125 MW; 2469DB553EA9050C CRC64;
LPFFPLNTHV LLYVDPISCR RQVDVWGSWG EWSKCSRSCG GGVSFRQRRC YSQRTEGPSS
CVGPARSYRS CNVQNCPEGS RDFRAEQCAE FDGTEFQGKK YKWLPYYGAP NKCELNCIPK
GENFYYRHKE TVVDGTTCEP GKRDICVEGV CQAVGCDNML ESAKKEDKCL QCGGDGSTCY
GVKGTFDVAS LPKGYNQIFI IPVGATSIQI KEVKPSRNFL AVKNVRGEYY LNGHWTIDFS
RALQVASTVL HYDRGSEGDV APELLHARGP TTEPLVIELI SQEPNTGVQY EYYLPLQGQA
LGYSWSYGSW SECSSECGGG FQSRLVFCTI DNEIYPDYMC RNKPQPDNNR TCGHQPCPQT
KRTSYIYLPQ AWSHSGARSS QMKSWKTGEW GSCSATCGGG TQTRSVYCVA FDGQSPQGVV
DDAECMAFAQ QPRRSQPCNV RQCASWSTGP WSQVTSCGEG VQTRTVTCRT QQGSQAQDFA
CLMEPKPSAT QPCLKENCIQ EIGWHVGDWG LCSKSCDSGI RTRQVICADG DSKFYSPETC
KAIQPQKPAT LGSCNTQPCY LPQQVPSMQD TMGYNVTLLS PDSDDGRMLP GNTMIHSASG
NQHIPSTKDH SINLFAVHWE PQSRSPGSHR LSFSQDHPAG TGSQDCHQSL HGCCPDGRTP
ASGPLGRGCP FSTCHQNRYG CCPDGVSAAQ GPNNIGCPQY SNIRTRQNHP TVTTPAVSTK
ALSLSQQHPS GECRSSMYGC CFDNVASAKG PRGEGCLNRP NYPYPVMCLL PSAHGPCANW
TTRWYFVGVV GRCNRFWYGG CHGNKNSFAS EEECMRVCHS SVGVSQLELQ ETASHIQEGK
IYGASLPKQD SHSWRRDVLP ETLPRTDVLE SQRWDTQRSR LDSLGHLHSW ETAMPGPSDR
TILEEAKPSL VTAAVGQNIQ LVCKTGVSPL SRVEWMKNSR PIFSDRHTYQ SDSSLVISHV
QPEDAGTYTC LTSDGRMESR QIQLQITGEF IFCPGPERPH RNKGGQIIFA LNEQGSFHIF
CCACKLCRLK MDKSEPTVVE ANIGERVRLP CTVEASPALT IEWQKDGQPL SSPRHRQQSD
GALVISRVSS EDIGFFTCMA SNGRDRDQRQ VLLRPLGELR ITGLLPSITV PEGGTAQLHC
TVTGNNVNIR WSRNGVPMRG DGHHIHLSQD GSLTISNVQE ADEGSYTCSA YRSSSSVSAS
SEVKVLRSRH IVDLSRECVD QPHLANCDLI LQAQLCGNEY YSSFCCASCA RHRSQGSPPH
PRG
//
