ID H0ZLX5_TAEGU Unreviewed; 821 AA.
AC H0ZLX5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=RNA binding motif protein 25 {ECO:0000313|Ensembl:ENSTGUP00000011598.2};
GN Name=RBM25 {ECO:0000313|Ensembl:ENSTGUP00000011598.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011598.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011598.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011598.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012429653.1; XM_012574199.1.
DR AlphaFoldDB; H0ZLX5; -.
DR STRING; 59729.ENSTGUP00000011598; -.
DR Ensembl; ENSTGUT00000011724.2; ENSTGUP00000011598.2; ENSTGUG00000011246.2.
DR GeneID; 100221046; -.
DR CTD; 58517; -.
DR GeneTree; ENSGT00730000111019; -.
DR HOGENOM; CLU_009855_0_0_1; -.
DR InParanoid; H0ZLX5; -.
DR OMA; DGCVNKK; -.
DR OrthoDB; 55687at2759; -.
DR TreeFam; TF320185; -.
DR Proteomes; UP000007754; Chromosome 5.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR CDD; cd12446; RRM_RBM25; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034268; RBM25_RRM.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR18806; RBM25 PROTEIN; 1.
DR PANTHER; PTHR18806:SF4; RNA-BINDING PROTEIN 25; 1.
DR Pfam; PF01480; PWI; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00311; PWI; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51025; PWI; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 88..165
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 728..821
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..584
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 97483 MW; FFA9C240DFE95A0B CRC64;
MSFPPHLNRP PMGIPTLPPG IPPPQFPGFP PPVPPGTPMI PVPMGIMAPA PTVLVPTTVS
MVGKHLGVRK DHPGLKNKEN DENCGPTTTV FVGNISEKAS DMLIRQLLAK CGLVLSWKRV
QGASGKLQAF GFCEYKEPDS TLRALRLLHD LQIGEKKLLV KVDAKTKAQL DEWKAKKKAS
NGNSRPETTT NDDDEALDEE TKRRDQIIKG AIEVLIREYS SELNAPSQES DSHPRKKKKE
KKEDEDINAI EMEEDKRDLI SREISKFRDT HKKLEEEKGK KEKERQEIEK ERRERERERE
RERERRERER EREREREKEK ERERERERDR DRDRTKDRDR DRERDRDRDR DRERSSDRKD
RSRSREKSRD RERERERERE RERERERERE RERERERERE REREKDKKRD REEDEEDAYE
RRKLERKLRE KEAAYQERLK NWEIRERKKS REYEKEAERE EERRREMAKE AKRLKEFLED
YDDDRDDPKY YRGSALQKRL RDREKEMEAD ERDRKREKEE LEEIRQRLLA EGHPDPDAEL
QRMEQEAERR RQPQIKQEPE SEEEEEDKAE KEEKREEPEE EEEEPEQKPC LKPTLRPISS
APSVSSASGN ATPNTPGDES PCGIIIPHEN SPEQQQLEEH RPKIGLSLKL GACNSPNQPN
AVKRKKLAVD SVFNKFDDED SDDVPRKRKL VPLDYGEEDK SNIKGSVNTE EKRKHIKSLI
EKIPTAKPEL FAYPLDWSIV DSTLMERRIR PWINKKIIEY IGEEEATLVD FVCSKVMAHS
SPQSILDDVA MVLDEEAEVF IVKMWRLLIY ETEAKKIGLV K
//
