ID H0ZMN1_TAEGU Unreviewed; 873 AA.
AC H0ZMN1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 4 {ECO:0000313|Ensembl:ENSTGUP00000011854.2};
GN Name=FGD4 {ECO:0000313|Ensembl:ENSTGUP00000011854.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011854.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011854.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011854.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; H0ZMN1; -.
DR STRING; 59729.ENSTGUP00000033757; -.
DR Ensembl; ENSTGUT00000011983.2; ENSTGUP00000011854.2; ENSTGUG00000011490.2.
DR GeneTree; ENSGT00940000155765; -.
DR HOGENOM; CLU_011755_1_0_1; -.
DR TreeFam; TF316247; -.
DR Proteomes; UP000007754; Chromosome 1A.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd15741; FYVE_FGD1_2_4; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF98; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 346..533
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 562..672
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 666..722
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 667..717
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 750..847
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 104..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 873 AA; 97978 MW; 27F7BE936D671B36 CRC64;
MQAGGEGGAA LGALRTPRPL PQSAFLRFSG APRTSGAEGA HFRRLAIRRK ASAAPGAGGA
RSPPAGSSIC PKPLILSRAC AAGATARLVE QNVRYDAAQG INGSVPLKQS PRSAASPKPQ
VPPKPIHLQK ATYQTPRHKA LTNQKPRMEE ETPAAVSSVT KEKSSKVSDL INRFEGGSSL
NPGDFKKDSS VLHITKSQGR YGSTPSPQPK LPSQHSLQKQ GHSTTDRTQV AQLPTANGVV
AQEQREEEER RWPERGSAVS TPVPDDAMDS SLINGEGESS RRESLQSVAA CEEQMLNSCH
RTPSSDTLLP PENETLGIDT DVKEEPAEEC NKQDQPVETK ETDEQKRHKI ANELLQTEKA
YVSRLDLLDG VFYSRLLEEA NRGSFPPEVI NKIFSNISSI NAFHSKFLLP ELEKRMQEWT
TTPRIGDILQ KLAPFLKMYG EYVKNFDNAM ELVKTWTERS PQFKFIIQDI QKEKVCGNLT
LQHHMLEPVQ RIPRYEMLLK DYLRKLPQDS LDWKDAEKSL EIISTAASHS NSAIRKMENL
KKLLEIYEML GEEEDIVNPS NELIKEGQIL KLAARNTSAQ ERYLFLFNNM LLYCVPKFSL
VGSKFSVRTR VGIDGMKIIE THNEEYPHTF QRNETFRNAI AKEYEDMPVE VSNAELGKRA
PRWIRDNEVT MCMKCKEPFN ALTRRRHHCR ACGHVVCWKC SDYKAHLEYD GNKLNKVCKD
CYHVIIGCTD SEEKKRKGIL EIESAEVSGN SVICSFLQYM EKSKPWQKAW CVIPKQEALV
LYMYGAPQDV KALATIPLLG YAVDDTPKSA DLPHSFKLTQ SKSVHSFAAD NEELKQKWLK
VIHLAVKGET PECQNELQVN LEEQPESSKR SEC
//
