ID H0ZN01_TAEGU Unreviewed; 179 AA.
AC H0ZN01;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Interleukin-7 {ECO:0000256|ARBA:ARBA00019460};
GN Name=IL7 {ECO:0000313|Ensembl:ENSTGUP00000011975.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000011975.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000011975.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000011975.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-7/IL-9 family.
CC {ECO:0000256|ARBA:ARBA00007621}.
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DR AlphaFoldDB; H0ZN01; -.
DR STRING; 59729.ENSTGUP00000011975; -.
DR Ensembl; ENSTGUT00000012106.2; ENSTGUP00000011975.2; ENSTGUG00000011619.2.
DR GeneTree; ENSGT00390000004451; -.
DR HOGENOM; CLU_129368_0_0_1; -.
DR InParanoid; H0ZN01; -.
DR OMA; NMSAEYR; -.
DR OrthoDB; 5322916at2759; -.
DR TreeFam; TF338065; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0005139; F:interleukin-7 receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 1.20.1250.50; -; 1.
DR InterPro; IPR001181; IL-7.
DR InterPro; IPR038325; IL7_sf.
DR PANTHER; PTHR48404; INTERLEUKIN-7; 1.
DR PANTHER; PTHR48404:SF1; INTERLEUKIN-7; 1.
DR Pfam; PF01415; IL7; 1.
DR PRINTS; PR00435; INTERLEUKIN7.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..179
FT /note="Interleukin-7"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025412531"
SQ SEQUENCE 179 AA; 20773 MW; 1BF5AF31BB8E5E58 CRC64;
MFHAFFRSTL PVLPLLLVLS PVKASSCAMG NKPTEIRVKY ENILSHDINE LVNMSAENRD
RCCKNNKKEN IKVFFCNDTE EIESLQSMAC NMLRFYNKQR ISKAFRQKAA FVSCGTLQVL
QCKCERPKKE KVCSHVFRIE DTETSEQSKK KCSQEVCELK ENISSLRSCW NKFEKLISR
//
