ID H0ZNA8_TAEGU Unreviewed; 658 AA.
AC H0ZNA8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Rho GTPase activating protein 18 {ECO:0000313|Ensembl:ENSTGUP00000012084.2};
GN Name=ARHGAP18 {ECO:0000313|Ensembl:ENSTGUP00000012084.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012084.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012084.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012084.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0ZNA8; -.
DR STRING; 59729.ENSTGUP00000012084; -.
DR Ensembl; ENSTGUT00000012218.2; ENSTGUP00000012084.2; ENSTGUG00000011721.2.
DR GeneTree; ENSGT00940000157142; -.
DR HOGENOM; CLU_023268_2_1_1; -.
DR InParanoid; H0ZNA8; -.
DR OMA; QHNMESQ; -.
DR TreeFam; TF314044; -.
DR Proteomes; UP000007754; Chromosome 3.
DR GO; GO:0005881; C:cytoplasmic microtubule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:2000145; P:regulation of cell motility; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
DR CDD; cd04391; RhoGAP_ARHGAP18; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF6; RHO GTPASE-ACTIVATING PROTEIN 18; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754}.
FT DOMAIN 315..516
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 74131 MW; 9450EB413597C420 CRC64;
MSWRSGSRGV VLTAYHPSGG AGDAPGGRRS GQYTMNHDHS KKIPDGASFD RSGSQDSLDE
LSMDDYWKEL ENIQETRGNN HEERVALVVK EPDEGELEEE WLKEAGLSNL FGESSGDSLE
SMVFLSTLTR TQKAAVEKRV ETVTQTMRKR NKQHQIPDVR DIFRLQNDAK GKVCDGSEPS
TVRTSENKNE THDGTKGPKF SLGTDEQKSL LEDMPSSDTD INLEISFSEQ AANLKESSAG
KIYIAGGGDT LLPNFRLPKD KTGTTKIGDL APQDMKKVYS LALIELTALY DILGTEFKQQ
KAVKIKTKDS GLFGVPLSLL LEQDQKKVPG TKIPLIFQKL IAQIEETTLE TEGLLRIPGV
ATRVKVKGLC QELEAKFYEG TFNWENVKQH DAASLLKLFI RELPQPLLTV EYLKAFQDVQ
NLPTRKQQLQ ALNLLVILLP EANRDTLKVL LEFLQRVIDH RDKNKMTLKN VAMVMAPNLF
TFHGFGSKTI EQSEFVMAAG TANVMRFMIQ YQKLLWTIPK FIVNQVRKQN AENPKKEKKD
KAMKKLLKKM AYDREKHEKQ EKTPNDTDVP QGVIRVQAPH LSKVSMAIQL TEELKAGDIV
ARFLSQKSGN VQTLKKEEVF LYEIGGNIGE RCLDDDTYMK DLYQLNPNAE WVIKPKQS
//
