ID H0ZP02_TAEGU Unreviewed; 3164 AA.
AC H0ZP02;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=FRAS1 related extracellular matrix 2 {ECO:0000313|Ensembl:ENSTGUP00000012331.2};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSTGUP00000012331.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012331.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012331.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012331.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 59729.ENSTGUP00000012331; -.
DR Ensembl; ENSTGUT00000012467.2; ENSTGUP00000012331.2; ENSTGUG00000011967.2.
DR GeneTree; ENSGT00940000155313; -.
DR HOGENOM; CLU_000394_0_0_1; -.
DR InParanoid; H0ZP02; -.
DR OMA; ILPWELN; -.
DR OrthoDB; 5470912at2759; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..3164
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025638281"
FT TRANSMEM 3104..3130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 298..392
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 417..515
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 538..663
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 688..799
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 820..911
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 937..1029
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1058..1160
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1181..1274
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1295..1391
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1412..1504
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1524..1613
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1647..1744
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1751..1850
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1863..1974
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1991..2095
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2110..2212
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2230..2334
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 3032..3056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3138..3164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3145..3164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3164 AA; 350659 MW; 7106BB6251C0F823 CRC64;
MQPLLTGPRR LLAGLLLLLA GCAWAGAAEP LSGSSAAVSS PWSPEADPVV VANRGLRVPL
GRSAWLDPAR DLVLQVQPGD RCHLTVLDED PLWQRPGRLS PRRFPCDFGA REVQYTHLGG
RSPARDRVRL QLRYDSPSRA LVLPLVLEVE VLFTQLEIVT RNLPLTVERL RGTSNPLDAR
SLEFAFEPGR QRCRVGLLPL LAGLPRYGEI LNYPPAATGG GGEAAGGGPM PSLMWDCEEF
LRLGLRYRHT AAGGSPNRDL VPLVAELREA AGGGALLKRE YFQVLVRIRA GSENVAPKPS
FLAMLMMEVD QFVLTALTPD MLSAEDAESP PDLLLFNITS PFGPGQGHMV STDDRSLPVT
SFSQRDVREL RIAYQPPTED SDRERLFELE LEVLDPEGAA SEPFTFVIVV KPMNTLAPVV
TRNTGLVLYE GQSRPLSGPG PSPNLVVSDE DDLEQVRVSV VAGLRHGHLT LLEDTPGPAA
PRKHFTVAEL AAGRVIYQHD GSESPLSDNL ILRLEDGGSR HRVEFLFPIT LVPTDDQPPL
LNANTGLAMA EGETVPITAR ALSATDIDSQ DAILLFTVES GPTAGQLLLR QAQPPPGWEE
EEEEEGFSWR KVPGVAGSSL IYEKPVREWL QQDIVEGRLF YHHFGAHSPG PGVVLDQFIF
RVQDDNDPPN RSGPQTFVIR VHPVDRLAPE LHSSSSLHLI VAEQQVTPLR RKHLCYTDQD
SGDRELRYTV IQPPTDTDTN HPPDTYGARL GSLVLTEDHS VEVTHFTQAQ INHHKISYRP
PQEELGVAPH LIQFQYQVQD AAGNVAKGTF TIYLQPVDNQ PPEITNTGFT LPEGGSHVLS
PTELDASDTD TELARLRFIL TQAPRYGQLQ LSGYSLVPGG IFGLEDIRQG RVVYVHSGAE
TNSDTCRLDV SDGVHFVPIT LKMSVHPVDD EVPMLRLPPG TLGSYLDVLE NGAAEITANV
IQGTDEDTDD FMLTFIVEDP PQHGSILVQG VPAERFSQRD LLDGAVVYAH TGGEIGLLPK
EDAFNLTLSD LSEKWHVRGN IVQGVSVLVT ILPVDSQAPE IFVGEQFVVT EGDKRVITLA
HLRAEDVDTP SDDILCTIVA QPTSGYVENI SPAPGSEKSR AGVAVSAFTL KDLRQGHIFY
VQSIHKGVEP VEDRFAFRCS DGINFSQRHF FPIVIVPIND EEPEIFLREF VVMEGMSLVI
DTPILNAVDA DVPADELTFT ITRLPRHGHI VNQLVNGTVL VESFTLDQIT ESSSILYEHD
DSETRVDGFE VQLSDGKHTI RKMVPIMVIS VDDETPRMAI NDGLEIEIGE TRTINNRILK
ATDLDSEDKT LTYIITYGPG QGLLQRIKSS GGVENITRGM NFTQDEVDRN LIRYVHFGQQ
GVRDLIKFDV TDGINPLIDR YFYVTIGSID IVFPDVISKG VSLKEGGKVT LTTDLLSTSD
LNSPDENLVF TITRPPVRGH LECTDQPGVP ISTFTQLLLA GNKIYYIHTS EDEVKMDSFE
FEVTDGYNPV FRTFRISISD VDNKKPVVTI HNLVVSENEY KLITPFELTA EDRDTPDALL
KFIITQIPIH GQIMFNNSKP VTTFTKQDLN ENLISYKHDG SESVEDSFSF TVTDGTHTDF
YVFPNTVFET RKPQTMKIRI MAVDNSVPQV VINKGAQTLR VLATGHIGFL ITNKVLKVED
RDSLHVTLKI RITEGPRHGF LIHLGKGNHS ISQFTQADID DMKICYVLRG SDNATSDIFH
FLVEDSGGNK LKNQHFRLNW AWISLEKEYY LVNEDTKYLD VVLKRRGYLG ETSFISISTK
DGTAKKDKDF RGKAQKQVQF NPGQTLATWR VRILSDGEHE HSESFQIVLS EPVMAILEFP
AASTVEIIDP GDESTVFIPQ STYTIEEDVG ELFIPVRRSG DVSQELMVIC YTQQGTASGT
APTSVLSYSD YISRPEDHNS ILRFDKDERE KTCRIVIIDD SLYEEAETFD VLLSMPMGGR
IGAEFPSTRI TIVPDKDDEP AFYFGNDEYY VDESAGYIEV RVWRTGTDLS KAASVTVRSR
KSEPATAEAG VDYVGISRNL DFSPGVNMQT FRVIILDDLG QPVLEGTEKF ELVLRMPTNA
ALGEPSKTTI FINDSVSDLP KMQFKESVYV ANENDGQVSA VIYRSGDIRY TSTVRCYTRQ
GSAQVMMDFE ERPNTDSSII TFLPGETEKP CTLVLMDDTF HEEEEELRLV LGTPRSDSSF
GASVGEQNET LIKIRDDADK AIIKFGETKF SVSEPKDTRQ VAIVKIPVLR LGDTSKVSVV
RVHTRDGSAT SGEDYHPISE EIEFKEGETQ HFVEIEVLFD GVREMREAFT VHLKPDENMV
AEIQTVKAIV YIEEMNSMAD VTFPSVPQVA SLLIYDDTSK AKDRASPIAG YPVICITACN
PKYEDFDKTG SICASENINN TLTQYRWLVS APTGPDGVTS PMKEIDFDTF FTSSKMITLD
SIYFQAGSRV QCAARAVNSD GNEGLELMSP IVTISTSEGL CQPRISGVVG AEPFSAKLRY
TGPEDPDYAN LIKLTVTMPH IDGMLPVIST RELSNFELTL SHDGTRVGNH KCSNLLDYTE
VKTHHGFLTD ATKNPDVIGE TIPYQYSPTI RGFNTLRFYR NLNLEACLWE FISYYDMSEL
LTDCGGTIGT DGQVLNLVQS YVTLRVPLYV SYVFHSPVGV GGWQHFDLQS ELRLTFVYDT
AILWKDGIGS PPEAELQGSL FPTSMRINEE GRLVVNFKTE ARFHGLFVMS HPASSLTSMV
MSVDHPGLTF SLSLIRSEPT YNLPVQQWSF LSDFAVRDYS GMYTVKLIAC TTAPHQEYSL
PVICNPREPI TFDLDIRFQQ VSDPVAAEFS LNTQMFLLSK KTLWLSDGSM GFGQESDVTF
SEGDVIYGRV MVDPVQNLGD SFYCSIEKVF LCTGADGYVP KYNPSNTEYG CLADSPSLLY
RFKIVDKAQP ETQATSFGNV LFNAKLAIDD PEAIPLVKQP GSDGFKVDST PLFQVSLGRE
WYVHTIYTVR SKENVNRGIG KRSVEHQYHS LLSAGSPGAS PRRRQKRGTE QAPELARDIG
VENNRGTNIQ HIALDRTSRK QVPQREVALN GVLPRELNNQ NAGISIVTII GGAAAVFLAI
CLIAIIVLLL KWKRNSDKKE STNESGSNEP MMLPHNYSND SSEV
//
