ID H0ZP16_TAEGU Unreviewed; 580 AA.
AC H0ZP16;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Metadherin {ECO:0000313|Ensembl:ENSTGUP00000012345.2};
GN Name=MTDH {ECO:0000313|Ensembl:ENSTGUP00000012345.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012345.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012345.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012345.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H0ZP16; -.
DR STRING; 59729.ENSTGUP00000034424; -.
DR Ensembl; ENSTGUT00000012482.2; ENSTGUP00000012345.2; ENSTGUG00000011979.2.
DR GeneTree; ENSGT00940000154181; -.
DR HOGENOM; CLU_034908_0_0_1; -.
DR TreeFam; TF331350; -.
DR Proteomes; UP000007754; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR InterPro; IPR031402; LYRIC.
DR PANTHER; PTHR23251; LYSINE-RICH CEACAM1 CO-ISOLATED PROTEIN LYRIC PROTEIN; 1.
DR PANTHER; PTHR23251:SF0; PROTEIN LYRIC; 1.
DR Pfam; PF15686; LYRIC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 96..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..521
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 62337 MW; 1239F0911820642C CRC64;
MAAGSWQEAA ARWAEEAAAR VRDALSGGLG LLRAELGLEL GLDPQALPAW LALAVPAALG
FVLLGLLLAA ACGGGLRKKP ARSAAVRKGD EAVGAGLTAG GGPGKAAGPG PGQLNLKGDE
QKKRNRKKLP ERAARPNGRS FIDVSEDEVI QTVRKDNIKQ PVDTEKKNEK SKKKKKSKGD
SKTVQDSSRL DGKEVDEGAW ETKISNREKR QQRKRDKVLN DGGSGESNLQ GIENTVTVPI
EQLMPTPSLP VGLRKNKGDA LLNAQINSSK PAKGESSIPQ VSPGLSESHT VNGGSWNEKS
VKISSQIGVG EEKWTSVPST AAGKRKTETL AWGQDTGDAN GNGKDWGVSL VGRPWKERSL
FTPIAAWNVD ARINTSEQNS ASFSSFGLTP GVSGSNSESV SQAGTSDFQW DLSHAQTPVD
DEWSGLNGLS SADPSSDWNA PAEEWGNWVD EEKVASVPQR EERSDTQKIS DNEREKAEQI
LQSSTSGKSK KKKKKKKKQG EEANSPAQDA EELDREAGEQ FQADTSKVQA QQERAFSLKT
ISTSEPAKQS LKKAGNLPNK LKRRKKQEGK REIPKMDMCC
//
