ID   H0ZPS1_TAEGU            Unreviewed;       271 AA.
AC   H0ZPS1;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=ER membrane protein complex subunit 2 {ECO:0000256|RuleBase:RU367091};
GN   Name=EMC2 {ECO:0000313|Ensembl:ENSTGUP00000012603.2};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012603.2, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Ensembl:ENSTGUP00000012603.2, ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA   Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA   Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA   Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA   McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA   Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA   Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA   Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA   Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA   Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA   Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000012603.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Part of the endoplasmic reticulum membrane protein complex
CC       (EMC) that enables the energy-independent insertion into endoplasmic
CC       reticulum membranes of newly synthesized membrane proteins.
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU367091}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU367091}; Cytoplasmic side
CC       {ECO:0000256|RuleBase:RU367091}.
CC   -!- SIMILARITY: Belongs to the EMC2 family. {ECO:0000256|ARBA:ARBA00010361,
CC       ECO:0000256|RuleBase:RU367091}.
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DR   AlphaFoldDB; H0ZPS1; -.
DR   STRING; 59729.ENSTGUP00000017488; -.
DR   Ensembl; ENSTGUT00000012743.2; ENSTGUP00000012603.2; ENSTGUG00000012231.2.
DR   GeneTree; ENSGT00390000011922; -.
DR   HOGENOM; CLU_052388_1_0_1; -.
DR   TreeFam; TF312997; -.
DR   Proteomes; UP000007754; Chromosome 2.
DR   GO; GO:0072546; C:EMC complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR039856; EMC2-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12760:SF0; ER MEMBRANE PROTEIN COMPLEX SUBUNIT 2; 1.
DR   PANTHER; PTHR12760; TETRATRICOPEPTIDE REPEAT PROTEIN; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU367091};
KW   Membrane {ECO:0000256|RuleBase:RU367091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803}.
SQ   SEQUENCE   271 AA;  31896 MW;  1465857C2B4F232E CRC64;
     MYDVTWEDMR DKMRKWREEN YRNSEQIVDV GEELINEYAS KLGDDIWIIY EQVMIAALDC
     SRDDLALFCL QELRRQFPGS HRVKRLTGMR FEAMERYDDA IQLYDRILQE DSTNTAARKR
     KIAIRKAQGK NLEAIRELNE YLEHYAKAAF CLEELMMTNP HNHLYCQQYA EVKYTQGGLE
     NLELSRKYFA QALKLNNRNM RALFGLYMSA SHIASNPKAS AKMKKDNMKY ASWAANQINR
     AYQFAGRSKK ETKYSLKAVE DMLETLQITQ S
//