ID H0ZQ83_TAEGU Unreviewed; 834 AA.
AC H0ZQ83;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Epidermal growth factor receptor pathway substrate 8 {ECO:0000313|Ensembl:ENSTGUP00000012770.2};
GN Name=EPS8 {ECO:0000313|Ensembl:ENSTGUP00000012770.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012770.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012770.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012770.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H0ZQ83; -.
DR STRING; 59729.ENSTGUP00000029413; -.
DR Ensembl; ENSTGUT00000012915.2; ENSTGUP00000012770.2; ENSTGUG00000012399.2.
DR GeneTree; ENSGT00940000156403; -.
DR HOGENOM; CLU_014510_0_0_1; -.
DR TreeFam; TF313069; -.
DR Proteomes; UP000007754; Chromosome 1A.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 530..589
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 298..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 92828 MW; 46EFA2D0507AFFA0 CRC64;
MNGHISNTPP GGYGSYFPQM NGYGSPTFAQ AEREQNSRTS AKALYEQRKN YARDSVSSIS
ETSQYHVEHL TTFVLDRKEA MITVDDGIRK LKLLDAKGKV WTQDMILQVD DKAVSLVDLE
SKNELENFPL STIQHCQAVM NACNYNSILA LICKEPTQNK PDLHLFQCDE IKATLIHEDI
ESAISDSKSG KQKKRLETLR MISKADSAIP PPPRAPAPVP PGTITQVDVR SRVAAWSAWA
SEQGDYEKHR QYHEQEETAE MIAARIDRDV QILNHILDDI EYFVTKLQKA AEAFAELSKR
KKTKKSKKKG PGEGVLTLRA KPPPPDEFVD CFQKFKHGFN LLLKFHIQNP SAADLVHFLF
TPLHMVVQTT GGPELASTVL SPLLTKDTID FLRYTVTSEE GQLWMSLGDS WTKARAEWPK
DHFIPPYVPR FRNGWEPPLL NFMGAPKEQE LNHLAESVAN VAEQQRKQEM KRLSSEPPGV
PDYPPADGYA FSNTVYKRGP LLDQGAAVAA FKQTVSRHVD RNYEAHNKAQ TKKYAKCKYE
FVARNNSELS VMKEEIVEIL DDRKQWWKVQ NKSGSTGFVP NNILDPLRSA EGGQGWPEPA
YTRTIQKQRM DYVAKQPDPA PATPSPPPTP APVPVAVPVA VPVAVPLPPS APAPIPVPVP
KAPAAVSRQS STSSDSGGSV ARDAQRQKQI PVDRRKSQME EVQDELVHRL TIGRSAAQRK
FHVPRPNIPV VNITYDSSPE DVKAWLQSKG FNPVTVNSLG VLTGAQLFSL NKEELRTVCP
EGSRVYNQIT VQKSALEASS GSSELQEIMR RRQEKISAAA TDSGVESFDE GSSH
//
