ID H0ZQI5_TAEGU Unreviewed; 963 AA.
AC H0ZQI5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease {ECO:0000313|Ensembl:ENSTGUP00000012874.2};
GN Name=DIS3 {ECO:0000313|Ensembl:ENSTGUP00000012874.2};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000012874.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000012874.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000012874.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR AlphaFoldDB; H0ZQI5; -.
DR STRING; 59729.ENSTGUP00000012874; -.
DR Ensembl; ENSTGUT00000013022.2; ENSTGUP00000012874.2; ENSTGUG00000012500.2.
DR GeneTree; ENSGT00530000063106; -.
DR HOGENOM; CLU_002333_5_0_1; -.
DR InParanoid; H0ZQI5; -.
DR OMA; VKVHMDS; -.
DR OrthoDB; 945235at2759; -.
DR TreeFam; TF105755; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0004519; F:endonuclease activity; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0071034; P:CUT catabolic process; IEA:Ensembl.
DR GO; GO:0006396; P:RNA processing; IEA:Ensembl.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:Ensembl.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 68..186
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT DOMAIN 471..801
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
SQ SEQUENCE 963 AA; 109280 MW; B1A6941D90C753D8 CRC64;
MLTSRTFVKR TRAGAVVKVV REHYLRDDIA CGAAACRLCP RAAPGGGSAP GLEARPGGPG
SSLCPGPHFL LPDTNLLLHQ IDILEDPVIK NVIVLQTVLQ EVRNRSAPVY KRIRDLIQNP
EKHFYSFTNE HHRDTYIEQK RGETSNDRND RAIRVAVKWY NEHLKKIEDE EKTQVIFLTN
DRINKEKALE EGITAYTCEE YIKSLTANPE LVDRLACVSD EGKEIEGGKI IFPEHIPLSK
LQQGIKSGIY LQGTYRANRE NYLEATVWVH GDAEENKEII VQGLKHLNRA IHEDVVAVEL
LAKDEWVAPS SVVLQDDGQN EENIENEEEK ENILKTSINK DMLRPTGRVV GIIKRNWRPY
CGMLSKSQIK EARRHLFTPA DRRIPRIRIE TRQADALEGQ RIIVAIDGWP RNSRYPNGHF
VKNLGSAGDK ETETEVLLLE HDVPHQAFSQ AVLSFLPKMP WSITEEDMKH REDLRHLNVC
SVDPPGCTDI DDALHCREIG NGNLEVGVHI ADVSHFIRPG NALDEESVKR GTTVYLCEKR
IDMVPELLSS NLCSLRSNVD RLAFSCIWEM NHKAEILKTR FTKSIINSRA SLTYAEAQMR
IDSATMNDDI TTSLRGLNKL AKILKKKRID NGALTLASPE VRFHMDSETH DPIDLQTKEL
KETNSMVEEF MLLANISVAQ KIYDEFPEFA LLRKHPAPPP SNYDILVKAA KSKNLEIKTD
SAKALAESLD KAESPTFPYL NTLLRILTTR CMMQAVYFCS GMDNDFHHYG LASPIYTHFT
SPIRRYADII VHRLLAVAIG ADSTYPDLTD KHKLAEMCKN LNYRHKMAQY AQRASVAFHT
QLFFKTKGVV NEDAYILFVR KNAIVVLIPR YGLEGTVFFE EKDKPTPKLE YNSEVPSLTV
EDTTLCVFDK VKVNVMLDDS NIQHQKMRMV LVEPKILGND MHASLSAEAS SKEEPEKKKM
RQK
//
