ID H0ZSA5_TAEGU Unreviewed; 1441 AA.
AC H0ZSA5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Alpha-2-macroglobulin like 1 {ECO:0008006|Google:ProtNLM};
OS Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC Estrildinae; Taeniopygia.
OX NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000013501.2, ECO:0000313|Proteomes:UP000007754};
RN [1] {ECO:0000313|Ensembl:ENSTGUP00000013501.2, ECO:0000313|Proteomes:UP000007754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20360741; DOI=10.1038/nature08819;
RA Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C., London S.E.,
RA Li Y., Lin Y.C., George J., Sweedler J., Southey B., Gunaratne P.,
RA Watson M., Nam K., Backstrom N., Smeds L., Nabholz B., Itoh Y., Whitney O.,
RA Pfenning A.R., Howard J., Volker M., Skinner B.M., Griffin D.K., Ye L.,
RA McLaren W.M., Flicek P., Quesada V., Velasco G., Lopez-Otin C.,
RA Puente X.S., Olender T., Lancet D., Smit A.F., Hubley R., Konkel M.K.,
RA Walker J.A., Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z.,
RA Eichler E.E., Stapley J., Slate J., Ekblom R., Birkhead T., Burke T.,
RA Burt D., Scharff C., Adam I., Richard H., Sultan M., Soldatov A.,
RA Lehrach H., Edwards S.V., Yang S.P., Li X., Graves T., Fulton L.,
RA Nelson J., Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT "The genome of a songbird.";
RL Nature 464:757-762(2010).
RN [2] {ECO:0000313|Ensembl:ENSTGUP00000013501.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR STRING; 59729.ENSTGUP00000014993; -.
DR Ensembl; ENSTGUT00000013654.2; ENSTGUP00000013501.2; ENSTGUG00000013107.2.
DR GeneTree; ENSGT00940000163990; -.
DR HOGENOM; CLU_001634_3_0_1; -.
DR TreeFam; TF313285; -.
DR Proteomes; UP000007754; Chromosome 1.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF178; ALPHA-2-MACROGLOBULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000007754};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1441
FT /note="Alpha-2-macroglobulin like 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025386357"
FT DOMAIN 446..596
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 723..812
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1349..1436
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1441 AA; 159368 MW; 1A64D053796D55C8 CRC64;
MRIAILLSLL FHAAAASHQL HYLVVIPAAL RYPSTQVACL HITCHEAKIQ VNLALERSAG
RELLMQETIQ KKKTFLCTKF WVAPPPDGTE EVATVKLTIT GDGVNVEEQK KVLICKARNG
TIIQTDKPIY EPGQTVKFRI VTLDEEFLAL NDSDPKNNQI EQWQNVVPQD GIADLSFQLS
DEPLLGTYVI NVTSARAYGS FSVKERGMST GVLPKFEVIF EAPNQIYALE ATFPLRVCGR
YTHGNSVQGM VHVNLCQKIA PFLPTASKPD LCYKFSNQTD EAGCFFANVS LSSFSRDFRY
YRDSIAAEAS LVEDATEIQV NASHKLLISR IGGMALFDDV NSYYHTGQMY RGKIKVIDYQ
GKALKNKEVL LVVNCADQQF RQKYITGDSG TAAFSLDTSA WNSTLASLEA SVLHQDSDRE
PGTVDLSYQR ASYFIHPFYS ISRSFLSITR VPETMPCGKT QAVQVDFRIY EEDLEHGPKR
VIFSYFVTGK RGIVHAGQQT VWVGLPRMLE GSFSIPLTFS LTYAPAPRLV VYVIFPNGKI
IADSAIFSVS TCFRNKVELS FSTPETLPGS QVGLRLQAAP GSTCAVWAVD PSAFWMKPGR
ELSSHSIFGL FPSVYNSRYP RQVSEDDRSC GFPNSDEPDV FTAFREMGLK IMSNTNIKKP
RVCPTTQLTT ILQERGTSIS RPMLTFAQPH KVYNKHLTST YQPTMFPPFY AAEEKAHKHF
HQTWLWDLYS VGPSGNKSIT VTVPDAITEW KAGMFCTGQN GFGFAPASRL IVSKPFLVEL
PLPSSVVQGE TFNLKATVFN NLQQCMRIQV TLEESAHFQL NPCKGCANSS CLCAGEAKTF
QWSVTAEQLG LMNITLSTEA VASKELCGEE IPFVPKQGQK DTITKLIQVR PEGVLVEKAH
SSILCPEKGN PAEESVSLVL PLNVVEGSVR ATVSVTGDLM GMALQNLDHL VQLPHGCGEQ
NMVLFAPVVY VLQYLEKTRQ LSPEIKDRAT GFLRNGYQIQ LQYQHPDGSY SEFGTKDEYG
NTWLTAFVVK CFVQAKPYIY LDNQIIQAAL TWLEFHQLPS GCFKNVGQLF HTFMKGGVDG
EVPLAAYITA AYLEAGATPE SSVVRRALGC IAPALPRAAS TYTQALLAYT FALAKDARRT
QELLDVLGRK AIRADGQIHW SQTSSKPRTS TSPWSQPVSV DVELTAYVLL ALLSKPNVTE
SDLATASGIV VWLTRQQNAY GGFASTQDTV VALQALAKYA ALTHSTQGDA EVRVRSLGGF
GKKFQVSYQN RLLVQEAALT EVPGKFLVQA HGSCCVFTRM VLRYYTPSPQ DSTSFALQVK
TEPVNCTKDN TLSVTVHVDV RYNGKKSTSN MVILEVSLLT GFALAPGSGV SLQHGHLVRR
TEKTQGGVAI YLDKLSHISD TYVLHLEQEI EVTNLKPGHV RVYDYYNPEE QALADYNVFC
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