GenomeNet

Database: UniProt
Entry: H0ZUL4_TAEGU
LinkDB: H0ZUL4_TAEGU
Original site: H0ZUL4_TAEGU 
ID   H0ZUL4_TAEGU            Unreviewed;       189 AA.
AC   H0ZUL4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   08-MAY-2019, entry version 44.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=HYAL3 {ECO:0000313|Ensembl:ENSTGUP00000014311};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
OC   Estrildidae; Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729 {ECO:0000313|Ensembl:ENSTGUP00000014311, ECO:0000313|Proteomes:UP000007754};
RN   [1] {ECO:0000313|Proteomes:UP000007754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20360741; DOI=10.1038/nature08819;
RA   Warren W.C., Clayton D.F., Ellegren H., Arnold A.P., Hillier L.W.,
RA   Kunstner A., Searle S., White S., Vilella A.J., Fairley S., Heger A.,
RA   Kong L., Ponting C.P., Jarvis E.D., Mello C.V., Minx P., Lovell P.,
RA   Velho T.A., Ferris M., Balakrishnan C.N., Sinha S., Blatti C.,
RA   London S.E., Li Y., Lin Y.C., George J., Sweedler J., Southey B.,
RA   Gunaratne P., Watson M., Nam K., Backstrom N., Smeds L., Nabholz B.,
RA   Itoh Y., Whitney O., Pfenning A.R., Howard J., Volker M.,
RA   Skinner B.M., Griffin D.K., Ye L., McLaren W.M., Flicek P.,
RA   Quesada V., Velasco G., Lopez-Otin C., Puente X.S., Olender T.,
RA   Lancet D., Smit A.F., Hubley R., Konkel M.K., Walker J.A.,
RA   Batzer M.A., Gu W., Pollock D.D., Chen L., Cheng Z., Eichler E.E.,
RA   Stapley J., Slate J., Ekblom R., Birkhead T., Burke T., Burt D.,
RA   Scharff C., Adam I., Richard H., Sultan M., Soldatov A., Lehrach H.,
RA   Edwards S.V., Yang S.P., Li X., Graves T., Fulton L., Nelson J.,
RA   Chinwalla A., Hou S., Mardis E.R., Wilson R.K.;
RT   "The genome of a songbird.";
RL   Nature 464:757-762(2010).
RN   [2] {ECO:0000313|Ensembl:ENSTGUP00000014311}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2012) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; ABQF01111865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSTGUT00000014484; ENSTGUP00000014311; ENSTGUG00000013899.
DR   eggNOG; ENOG410JJ6D; Eukaryota.
DR   eggNOG; ENOG411147M; LUCA.
DR   GeneTree; ENSGT00950000182708; -.
DR   InParanoid; H0ZUL4; -.
DR   OMA; CSIRICH; -.
DR   Proteomes; UP000007754; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0033906; F:hyaluronoglucuronidase activity; IEA:Ensembl.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0071493; P:cellular response to UV-B; IEA:Ensembl.
DR   GO; GO:0030214; P:hyaluronan catabolic process; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR   GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
DR   GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR027260; Hyaluronidase-3.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   PANTHER; PTHR11769:SF19; PTHR11769:SF19; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01186; EGF_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007754};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007754}.
SQ   SEQUENCE   189 AA;  20695 MW;  AAEA4B918684BEB8 CRC64;
     YTGQCQPAEV QRNNHLGWLW AASSALYPSI YLPPALPPAL RRRYVHHRLR EALRVAAFGP
     DGLLPVIAYS RLAFRRSSRF LQLADLVHTI GESAALGAAG LVLWGDMSYS RSAESCASLR
     HYLVSTLGPY VANVTAAARE CSYGQCHGHG RCVRRQPHDL GSLLHLGPGA SPQAAFRCHC
     YRGWAGENC
//
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