ID H1CZA9_9FIRM Unreviewed; 622 AA.
AC H1CZA9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:EHO63277.1};
GN ORFNames=HMPREF9453_00702 {ECO:0000313|EMBL:EHO63277.1};
OS Dialister succinatiphilus YIT 11850.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Dialister.
OX NCBI_TaxID=742743 {ECO:0000313|EMBL:EHO63277.1, ECO:0000313|Proteomes:UP000003277};
RN [1] {ECO:0000313|EMBL:EHO63277.1, ECO:0000313|Proteomes:UP000003277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 11850 {ECO:0000313|EMBL:EHO63277.1,
RC ECO:0000313|Proteomes:UP000003277};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Dunbar C., Gearin G.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Lui A.,
RA MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Dialister succinatiphilus YIT 11850.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO63277.1}.
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DR EMBL; ADLT01000017; EHO63277.1; -; Genomic_DNA.
DR AlphaFoldDB; H1CZA9; -.
DR STRING; 742743.HMPREF9453_00702; -.
DR PATRIC; fig|742743.3.peg.711; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_1_9; -.
DR Proteomes; UP000003277; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003277};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..232
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 279..596
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 622 AA; 68306 MW; 3D40A7D6A6F35161 CRC64;
MKKRIPSILD SLVKNREESR YGRMIYAAMI LLLILSARLF WMQVVEGNYY KEEADGNRIR
HLPQQAARGV MYDRNGVIMA GSRPAYSVIM PVERKKNTLS DEELDRLAAL LKVKPEDIKK
KIDDNKLAFG AIYLANDVGI DVATQIEEKK DDFPGIEIEV NPLRVYPLGA AGAQVLGYVG
EAGPDDRDAE GNPYKTATLV GRSGLERQYN KFLEGKNGSK TVEVNASGQP VRYVEGTPAV
SGNNVRLTLD ANLQKAAEDA METQVRTLAH SGVFPTGASA VAIDPNTGAV LAMASWPSYD
PNHFSKGITA DEWNKIINNK NHPMQNRTIA AMYPPGSLFK VITGSAALEA KVTTPEERIF
DSGKHWLVDK RNSEGEAFGW INFYEAVEKS DNVYFYEMGR RLGIDRISAM AGEYGLGKPT
GIDLAGEAEG NVASEEYKRK VFKQDWYLGE TMDAAIGQSF TLTTPIQMAM VYSSIANGGF
RYKPYLVNRI DKLDGSPLKI YSPEKLGTLP VSKATLDDLH QALRLVMTKN GTGGALFANY
PIAMAGKSGT AETNGLDNGW FVAYGPFDKP EIVVLCMFEH SGFGSESAAP VVKQIMNAYF
HLGDYAPGKN KDEKKDKNGG NH
//
