ID H1CZR6_9FIRM Unreviewed; 637 AA.
AC H1CZR6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=HMPREF9453_00854 {ECO:0000313|EMBL:EHO63264.1};
OS Dialister succinatiphilus YIT 11850.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Dialister.
OX NCBI_TaxID=742743 {ECO:0000313|EMBL:EHO63264.1, ECO:0000313|Proteomes:UP000003277};
RN [1] {ECO:0000313|EMBL:EHO63264.1, ECO:0000313|Proteomes:UP000003277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 11850 {ECO:0000313|EMBL:EHO63264.1,
RC ECO:0000313|Proteomes:UP000003277};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Dunbar C., Gearin G.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Lui A.,
RA MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D., Pearson M.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Dialister succinatiphilus YIT 11850.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO63264.1}.
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DR EMBL; ADLT01000018; EHO63264.1; -; Genomic_DNA.
DR RefSeq; WP_008859358.1; NZ_JH591187.1.
DR AlphaFoldDB; H1CZR6; -.
DR STRING; 742743.HMPREF9453_00854; -.
DR PATRIC; fig|742743.3.peg.869; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_9; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000003277; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000003277}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 454..594
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 346..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 70658 MW; 4F1EB99164169BED CRC64;
MAVIHILDEV TANQIAAGEV VERPVNAVKE LVENAVDASA SSIEVEIADG GMTYIRVTDD
GCGMTEEDAK LSVIRHATSK ISSVDNIYHI ASLGFRGEAL PSIASVSRAT ITTRRSEDNE
GTVLEMTGGE ITEVKPAGAP AGTTVEVRDL FYNVPARKKF LKSERTESSR INSMVGKLAL
ANPDIAFRLI NNGRTVIETP GNGRLMDVVS ALYGTKTAGE MLPVEEEGEH IALEGLISKP
SLLKSSRQYQ TIIINRRVVD SAVVSKAVDN AYHSLLPKNG YPLMVLSFQV PPESIDVNVH
PQKREIKFSD EQSVFRLVYH GVLGTLTSQS TADTIAREMI HDPGHEVVKE HDFNPGSIRV
EDKPLGKPDI GLSEETRPKS SWGEPSPSYE ESRGQGADHF GERRAPSFAP DTEEKDLFTN
HSVFDEYRKE EPKREHLETD PLFEEEKQED PVIPLGQVSD CFILCQHGKD LLIIDQHAAH
ERVRYDHLAE RAEGIPVQEI LIPYLIHVDS GDVNLLEDHR ADIEKLGITF EQAGPDVIRI
TGSPEDLSAA EMERVMGDIV KAYHEKDVPS PETMRHRMMA YAACRGAIKR GDPLNIRQMK
ELIRDLFHTS RPFVCPHGRP TIVKFTPVEL GRLFKRP
//
