ID   H1HIU1_9BACT            Unreviewed;      1810 AA.
AC   H1HIU1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN   ORFNames=HMPREF9944_00085 {ECO:0000313|EMBL:EHO74848.1};
OS   Segatella maculosa OT 289.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Segatella.
OX   NCBI_TaxID=999422 {ECO:0000313|EMBL:EHO74848.1, ECO:0000313|Proteomes:UP000003167};
RN   [1] {ECO:0000313|EMBL:EHO74848.1, ECO:0000313|Proteomes:UP000003167}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OT 289 {ECO:0000313|EMBL:EHO74848.1,
RC   ECO:0000313|Proteomes:UP000003167};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA   Mathney J., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Prevotella maculosa OT 289.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHO74848.1}.
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DR   EMBL; AGEK01000005; EHO74848.1; -; Genomic_DNA.
DR   STRING; 999422.HMPREF9944_00085; -.
DR   PATRIC; fig|999422.3.peg.83; -.
DR   HOGENOM; CLU_001849_0_0_10; -.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000003167; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003167}.
FT   DOMAIN          1117..1207
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1810 AA;  205354 MW;  5DE8290B2ED5639A CRC64;
     MPPRAERCVG GRSSKQRMDM KKAICTIVVA LMMPLAVMAD SYGSLWKQYE LLQRKNQPRS
     AIHVLEQIAA KARADKAYGQ LIKAQFGLMD AWEDLAPDSL GPQLQRLRGE ALRAEKTDRA
     AAAIYYSVLG SRYRDRFAGN ADSMEVADAL LRKSMQEPAL LAATKAENYE PLMIGGSDSQ
     IFHNDLLHVL GFVTKDYRTL HRWYDAHGNR SAACYCALQL LKDERQDNVF ESKKSKYLQR
     LDSLITCYGD LPVGGELGIA RYEFMDLADD VSAEEKMNYL NYALAKWGTW PRMNILRNAR
     SRLTLPSFLA ECGPQVLLPH KERVVRIRQL TNIQSLTMSV TRLNTKAYCP LNPADKHDYA
     KIEKLLLAPT TTSVTHRYVG LPNYKVSSDS MTVGPLEKGV YLIEFTTDNK DIRPVRMLLH
     VSDMYVLESG LPNDRMRLIA MSATTGRPIA NAKIRIFSRT YQESKRSLKA TLTVDRQGEA
     SYKRSKEEYD VYCQAFTAAD DFCPPCSSTS YYASGNDYWK EDEEDFITRQ VQLFTDRSLY
     RPGQQVRVSM VDFTVNDRTK KASVNANDSI ALTLYDADYK ETETKKVRTD EYGTASVVFD
     LPKSGKTGLF TIEANDDFET SFHVEEYKRP TFTVDFTPYT KSYKNGDTIS VEGTAKSYAG
     VPVQGAKVVC SVVRRPNWFW WRGSDESRVT VKEDTLMTDE AGHFVIRVPL HLPEGKNNLP
     RYYTYDISAT VTDGAGESHE GMIALPFGNR SVYFNCNLPE RINRDSLTRF TFIYKNLAGE
     NVAAKVYYKV DDAPYQANSN EEVSLDYPRL KSGYHTLEAV CGEDTLRRSF VLFSLKDKRP
     TENTPDWCYT TSNQFGNDGK PVYVQLGSSL KDVYVAYTML SGSKVLESGT FTLNDEMYTR
     AFKYKETYLD GITVAYAWVK DGVLHSHNIN IRRPDPQLNL HAKWITFRDR LTPGQHETWT
     LQLTDKDGKP ARAQLMATMY DMSLDDIYLH SWDTGVRFSW DLASIQWAGT RFDNWQFYGE
     MPLKLLNVRG FNFTHIGWDI ASHLQGKVYG LRGMKNESMS DTVVLAKEEV ASNLFGARSS
     ELHEEVVTTG YAPRKKREAD MPKPQKSISL RKNFNETAFF FPALQTDSKG NVSLKFTLPE
     SVTTWRLLGY THDKDMNDAL IEATAVAKKS VMIMPNMPRF VRMGDKAVLS NRIVNTTDKP
     LSAQVEMHLL DSKTEKQVMA ETKSITLEAN ATANANFVFV PSQLRAMGYQ GDAVVCRMTI
     EGKAFSDGEQ HLLPILSDME HVVTTLAFSQ HEPGTKTFDI DKLFPVKEDS NKLTVSYTNN
     PAWMMVEALP TVAHASTKDA ISLAAKYYAN TLSAYLMQLA GQTDSLEAAN RYKEEALFGL
     RQLQRADGSF SWWPGMSGSL YMTVAVTEML QRLNMMTGEQ QATRNLIANS MKFMAKEVKK
     DVVRLKAWEA KGYKNLLPSE TDLQYLYICA LRKENLDNAD NKYLLNLVEK RHTLFTIYGK
     AMMAVILGRN GHNMKLAQEH LKSLKEYTVY TDEMGRYFDT KRAGYSWFDY RIPTEVAAIE
     ALKIITPNDK QTISEMQRWL LQSKRTQSWD TPINCVDAVY AFMQGETKES LTNYGNNTLL
     TLNGEKLCTT EPTAGRAVVK AEKTGKTFGT LTAEKQSNNI SWGAIYAEYD QKLKDIDSQA
     TQLAVTRQLI NADGKMAKIN QDFKVGDKIK VRITLKADRD YDFVEVEDKR PACLEPVDQT
     SGYNFRYYYA PGDRATRYYF DRLPKGTHII ETEYYIDREG SYSSGICTAR CTYSPEFAGR
     DKAIQLNNEK
//