ID H1HK04_9BACT Unreviewed; 554 AA.
AC H1HK04;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=AspT/YidE/YbjL antiporter duplication domain-containing protein {ECO:0000313|EMBL:EHO72905.1};
GN ORFNames=HMPREF9944_00498 {ECO:0000313|EMBL:EHO72905.1};
OS Segatella maculosa OT 289.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Segatella.
OX NCBI_TaxID=999422 {ECO:0000313|EMBL:EHO72905.1, ECO:0000313|Proteomes:UP000003167};
RN [1] {ECO:0000313|EMBL:EHO72905.1, ECO:0000313|Proteomes:UP000003167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OT 289 {ECO:0000313|EMBL:EHO72905.1,
RC ECO:0000313|Proteomes:UP000003167};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Blanton J.M.,
RA Mathney J., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Prevotella maculosa OT 289.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family.
CC {ECO:0000256|ARBA:ARBA00009854}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO72905.1}.
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DR EMBL; AGEK01000016; EHO72905.1; -; Genomic_DNA.
DR RefSeq; WP_008564210.1; NZ_JH594501.1.
DR AlphaFoldDB; H1HK04; -.
DR STRING; 999422.HMPREF9944_00498; -.
DR PATRIC; fig|999422.3.peg.494; -.
DR HOGENOM; CLU_035023_3_1_10; -.
DR OrthoDB; 9155749at2; -.
DR Proteomes; UP000003167; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR006512; YidE_YbjL.
DR NCBIfam; TIGR01625; YidE_YbjL_dupl; 2.
DR PANTHER; PTHR30445:SF3; TRANSPORT PROTEIN YIDE-RELATED; 1.
DR PANTHER; PTHR30445; UNCHARACTERIZED; 1.
DR Pfam; PF06826; Asp-Al_Ex; 2.
DR Pfam; PF02080; TrkA_C; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003167};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 190..273
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 281..365
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 401..438
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 554 AA; 59478 MW; 091D384C75078040 CRC64;
MDWINSLFTT HSSIQTVVVL SMIIACGLAL GKLKVMGVSL SIAFVFFVGI LAGHLGFSID
PVVLDYAETF GLAIFVYCLG LHVGPNFFGS LRHEGMSENL WSLAIIIVGT LFSLLLIPLT
GVSLPDMVGL LCGATTNTPA LGAATQALSH LGMSSGTVAL ATAVSYPLGV LGVIIAMVIL
RKCFVKPADL ALRSVDSNDH TYIAEFEVIN PATTEKRIID VSHMTHLKFI ISRIWRGNEV
IVPTAETVLK ANDDLLVITN KEDEGAMEIL FGRKINKDWN KEAIDWNAID TQVESRVLVL
TRTGLNGKRL GELHLRKSYG VNVSRVIRGD IKLLATEDLR LQYGDRVTVV GQREAINHVE
GYFGNSVKTL NEPNIGSIFL GIILGLALGT IPISIPGMES SVRLGIAGGP IIMGIIIGAL
GPKLHFISYT TRSASLMLRK LGLSLYLACL GLDAGKDFFG TVMRPQGLLW VGIGALITIV
PVLIVGLIAL KTKKFDFGTI CGILCGSMAN PMALGYANDT LKGDTASISY ASVYPLGMFV
RVIIAQIIVM FFAT
//
