ID H1PKQ2_9FIRM Unreviewed; 646 AA.
AC H1PKQ2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=HMPREF0380_00760 {ECO:0000313|EMBL:EHO85908.1};
OS Eubacterium infirmum F0142.
OC Bacteria; Bacillota; Clostridia; Eubacteriales;
OC Eubacteriales Family XIII. Incertae Sedis.
OX NCBI_TaxID=883109 {ECO:0000313|EMBL:EHO85908.1, ECO:0000313|Proteomes:UP000004504};
RN [1] {ECO:0000313|EMBL:EHO85908.1, ECO:0000313|Proteomes:UP000004504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0142 {ECO:0000313|EMBL:EHO85908.1,
RC ECO:0000313|Proteomes:UP000004504};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Ganesan A.,
RA Baranova O.V., Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Heiman D., Howarth C., Larimer J., Lui A.,
RA MacDonald P.J.P., McCowen C., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P., Stolte C.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Eubacterium infirmum F0142.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
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DR EMBL; AGWI01000010; EHO85908.1; -; Genomic_DNA.
DR AlphaFoldDB; H1PKQ2; -.
DR STRING; 883109.HMPREF0380_00760; -.
DR PATRIC; fig|883109.3.peg.754; -.
DR eggNOG; COG0557; Bacteria.
DR HOGENOM; CLU_002333_4_1_9; -.
DR Proteomes; UP000004504; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR011129; CSD.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR013223; RNase_B_OB_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF08206; OB_RNB; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00357; CSP; 2.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000004504};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 566..646
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 646 AA; 73898 MW; A10D5AB8B0AECD1C CRC64;
MSKKSKSKKK LITGEIYKAK GGFGFLKCDA FEKDVFIARK HMKDAMDGDI AEVALIPMPL
WENGPEGFVV NIKERMVTEL VGTLDKSGKN GFLIPIEKRL KEDVFIPSKW LRGAKNGDKL
LVKIRKYPQD DRLAEGEVLK IIARKDDSDR DIKALIYEHD VSVEFPKEIE AETRKVADLV
LEYTDTGSRL DLRKEEIITI DGAYSKDLDD AVSLKKNEKG NFVLGVHIAD VSEFVREGMA
LDAEALNRGN SIYLIDHVVP MLPVLLSNKL CSLNEGEDRF TLSCIMEIDR RGKVQEYKIC
ESIIKSSARL VYDEVSDFLE HGKANAKLEA HGAMLKDMQE LAECLKKARE ELGSIDFDID
EAEFEIDKDG VPVDISLTER RTANLLIEEF MLVANRTVAE HYFWMEYPFI YRVHEKPLPE
KVMELKSFLK GIGISLPLNE GNIHPLALRN LLEEADKDGK LSLVSAVMVR SMQKAFYSPE
CLGHYGLAFK QYCHFTSPIR RYADLWIHRM IKHQMHEELS DEQLSKYHEK AKKVSDIVSE
TERKAISMER ELEKLKKAQY MERWVGYEEQ GVISGITSFG IFVQLPNTVE GLVRFDTLTD
DYYEFDQENY RLVGCNHGRE FRLGDSVKVV CTRVDTLIGT IDFRLS
//
