ID   H1PZL8_9BACT            Unreviewed;       305 AA.
AC   H1PZL8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=3-phosphoglycerate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF9140_00106 {ECO:0000313|EMBL:EHO75063.1};
OS   Prevotella micans F0438.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=883158 {ECO:0000313|EMBL:EHO75063.1, ECO:0000313|Proteomes:UP000016023};
RN   [1] {ECO:0000313|EMBL:EHO75063.1, ECO:0000313|Proteomes:UP000016023}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0438 {ECO:0000313|EMBL:EHO75063.1,
RC   ECO:0000313|Proteomes:UP000016023};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA   Blanton J.M., Wade W.G., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Prevotella micans F0438.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC       ECO:0000256|RuleBase:RU003719}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHO75063.1}.
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DR   EMBL; AGWK01000001; EHO75063.1; -; Genomic_DNA.
DR   RefSeq; WP_006950997.1; NZ_JH594521.1.
DR   AlphaFoldDB; H1PZL8; -.
DR   STRING; 883158.HMPREF9140_00106; -.
DR   PATRIC; fig|883158.3.peg.115; -.
DR   eggNOG; COG1052; Bacteria.
DR   HOGENOM; CLU_019796_1_3_10; -.
DR   Proteomes; UP000016023; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016023}.
FT   DOMAIN          17..304
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          123..248
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   305 AA;  33369 MW;  B9D2B7EE4F220F74 CRC64;
     MKVLIATEKP FAPAAVEDIK KELATAGHEI VLLEKYTDNA QLLEAVKDAD AMIVRSDKIT
     PAVLDSAKNL KIVVRAGAGY DSIDTAYAKE KNVVVENTPG QNSNAVAELV MGMLVYAVRN
     FYNGKAGSEL KGKRLGILAF GNVGRNVARI AKGFGMEVSA YDAFCPADVI EQAGVRAVKS
     QDELFQTNDI ISLHIPATPE TIKSIDYRTV NQMPKEGILV NTARKEVVNE EELVKLMSER
     KDLKFITDIK PDLDEEFKKF EGRYFSTPKK MGAQTAEANS NAGIAAAKQI NSFFAEGDTR
     FQVNK
//