ID H1Q4W9_9BACT Unreviewed; 1845 AA.
AC H1Q4W9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Alpha-2-macroglobulin domain-containing protein {ECO:0000259|SMART:SM01360};
GN ORFNames=HMPREF9140_01957 {ECO:0000313|EMBL:EHO66130.1};
OS Prevotella micans F0438.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=883158 {ECO:0000313|EMBL:EHO66130.1, ECO:0000313|Proteomes:UP000016023};
RN [1] {ECO:0000313|EMBL:EHO66130.1, ECO:0000313|Proteomes:UP000016023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0438 {ECO:0000313|EMBL:EHO66130.1,
RC ECO:0000313|Proteomes:UP000016023};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA Blanton J.M., Wade W.G., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Prevotella micans F0438.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHO66130.1}.
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DR EMBL; AGWK01000056; EHO66130.1; -; Genomic_DNA.
DR RefSeq; WP_006953602.1; NZ_JH594523.1.
DR STRING; 883158.HMPREF9140_01957; -.
DR PATRIC; fig|883158.3.peg.1958; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_001849_0_0_10; -.
DR Proteomes; UP000016023; Unassembled WGS sequence.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016023};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1845
FT /note="Alpha-2-macroglobulin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003553811"
FT DOMAIN 1099..1189
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1845 AA; 210091 MW; 7156A0ED0A1FD5E9 CRC64;
MKKILISLLM MLSTPFTLWG QTYEVLWKQV KEAENKDLPK TQIKVLEKIR SKAAREKSYG
NLLAAELLSS SLWTQISPDS AATQKEYLKK RVAESEKKDA VLGAVYNCAL GRLFEFDESE
NKDDYYKKAL EHPELLAQHK MSEFNPLIAK GTDDNIFAND LLHVIGMEVE NYAALNRFYV
ARGNREAACY TALLMVRDKK DELSRLDSII KLYGDLPICG EVAVRKYDVI KEDKTNKELI
KFIDESLERW KSWQGIKALA NERKELTNPT FGTKAIGAQI IAGKNDQKLF VNMRNIKDLT
LTITRTKLDG STTLNPEYNK ELEKIKKELQ PETQHVFKRT YSGHEAYEFF EDSIQLPALK
EGVYLVKFES STKNMPSIYR LLYSSNLFLM TEQQAKNKIR YVVVDASSGQ PVPGAKLKLF
FDERYKRKAY TEILTANKDG EAIFNLKEDR PYTVYVYTDK DRGCKIAGIY NNFSYSNYSV
SNVTSRVFTD RVIYRPGQKV NVAAVVYHYS NSELKTRVQA GQTFEIELRN ANYEIVASNK
VTTDRFGTAS TSFDLPSSGL TGSFSVIAKI GLNGSASFNV EEYKRPTFEV TFDEYKEAYT
AGDTIKLKGR AKSFAGVPVQ NAKVHYTVNR QQAFWWWRSP DNDEQVFEDD VKTDAQGEFT
VTLPFVIPEE NSEYHYARFF NFEVNADVTD LAGESRQGYA SLPLGTQPTA FSSNMKEKNL
KDELKSVTFN YLNAAGKQLE GQVKYAIVPY ADFKAKDPYK NYATAEANKP VQLKPMTSGR
YHLHALCGKD TLDTDFYVFS LTDRRPVIET HDWFYATDSR FSNDGKPVYI QMGSTDANQH
VVYSIYSGNK IIETGAFDQS NAITTRTFTY KEEYGDGITL NVAWVKDGEL YRHSHSIARP
LPDKRLLVKW KTFRNKLTPG QKEEWTVTIQ RPDGKAADAQ LMATLYDKSL DQILAHSWSL
SPSFYDNIPQ TSWNTYYRQM LNVSSSANIS YQSVGNLSFA GFDIRFLDGF ESESGFRYGY
INRQLQGNLA GITVNAYAPM KDVAYDSVES NEDFNKSEDA YETRAKIKFT APVIKKDEVQ
KSDTKLKKDV QLRENLNETA FFYPQLQTDS EGNISIKFTL PESLTTWRFI GVAHDEDLNN
GAIEDEAVAQ KTVMVQPNIP RFVRRGDAAT ISSRLFNTSD KEVKGTCTLE LIDPETDTVV
YSENKQVVIT AQGSASETFS IAKLLDNYSQ TLSADQSLLI ARVSIVGDNY SDGEQRYLPI
LPNMEFVTNT HPFTQNQPGT ETIDLTKLFP KRTTGQRLTV EYTNNPAWLM IQALPYVAYN
YSNNAVSLSS AYYANKLAEK ILKASPEIKE TILQWKQEKG TETSMMSALQ KNQELKELVL
NETPWVADAN NEAKQKQNLM QFFDENSIRN QLSTTLSEIK KLQKSDGAFS WYCDMLPSFY
MTITVVKTLA RLQILTGESE SGVTSIINSS FRYLDKEVAW QVKEMKKNEK KYKYTAIPSD
ELCNYVYINA LLKRPETADI SYLVDRISKK PTELTIYGKA LTAVILKQHN KTAKAMEYLQ
SIKEYTVYNE EKGRYFDSRN AYYSWRDYKI PTEVAAIEAL KLITPTDRQT IEEMQRWLLQ
EKRTQAWDTP LNSVDAVWAF MNDGKWSIDN GPQSVLKIDG SILETPKATA GLGYVKTVRS
IDQNQKPVKT FTVEKTSTGT SWGAVYAQFF QPVTEVAESA AGLKVKREIL TEKKTDQLKV
GDKIVIRLTI TADRDYDFVQ LIDKRAACLE PLNQISGYHW GYYIAPKDYT TNYYFDLMAK
GKHIIETEYF VDREGTYQTG ICTVQCAYSP EYSGRTGAVK FNVDK
//