ID H1RZ79_9BURK Unreviewed; 808 AA.
AC H1RZ79;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EHP44452.1};
GN ORFNames=OR16_03042 {ECO:0000313|EMBL:EHP44452.1};
OS Cupriavidus basilensis OR16.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1127483 {ECO:0000313|EMBL:EHP44452.1, ECO:0000313|Proteomes:UP000005808};
RN [1] {ECO:0000313|EMBL:EHP44452.1, ECO:0000313|Proteomes:UP000005808}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OR16 {ECO:0000313|EMBL:EHP44452.1,
RC ECO:0000313|Proteomes:UP000005808};
RX PubMed=22461549; DOI=10.1128/JB.06752-11;
RA Cserhati M., Kriszt B., Szoboszlay S., Toth A., Szabo I., Tancsics A.,
RA Nagy I., Horvath B., Nagy I., Kukolya J.;
RT "De Novo Genome Project of Cupriavidus basilensis OR16.";
RL J. Bacteriol. 194:2109-2110(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHP44452.1}.
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DR EMBL; AHJE01000007; EHP44452.1; -; Genomic_DNA.
DR RefSeq; WP_006156437.1; NZ_AHJE01000007.1.
DR AlphaFoldDB; H1RZ79; -.
DR PATRIC; fig|1127483.3.peg.617; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000005808; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 8..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 194..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 808 AA; 86153 MW; 9E5A426EF3F3252B CRC64;
MSNFIVKKVA VLGAGVMGAQ IAAHLVNARV PVVLFDLPAK EGPKNGISLR AIENLKKLSP
APLGIKDEAG LIQAANYEDD LALLKECDVV IEAIAERMDW KHDLYKKVAP HLASHTIFAT
NTSGLSITAL SDGFDADLKS RFCGVHFFNP PRYMHLVELI PTATTQPAIL DRLETFLTSA
LGKGVVRAKD TPNFIANRVG IFSILAVFAE AEKYGIPFDV VDDLTGSKLG RAKSATFRTA
DVVGLDTMAH VIKTMQDTLQ DDPFAPVYKT PAVLKALVDA GALGQKTGAG FYKKEGKAIK
VMDPTTGQYV DAGKKADEIV VRMLKKEPAE RIKLLRESTN PQAQFLWAVF RDVFHYIGVY
LEQIAGSAAD IDLAIRWGFG WNSGPFEDWQ SAGWKQVAEW VKEDIDAGKG LSSAALPSWV
FEGPVADNQG VHGAQGSWSP AAQAFVQRNA LPVYERQVFR AAVKGTAAAD PRKAGRTVEE
NDAVRIWVSE GQDDVLVVSF KSKMNTIGPD VIDGLTRAID LAQAEYKGLV VWQPTSLQLG
APGGPFSAGA NLEAAMPAFM MGGAKGIEPF VKKFQDGMMR VKYSAVPVVS AASGIALGGG
CELMLHSAKR VAALETYIGL VEVGVGLVPA GGGLKEAALA AARAAQAAGS TNYLQFLTNR
FQAAAMAKVS ASALEAQKMG YLQPSDTIVY NVHELLYVAQ GEVRALANAG YRAPVPGTLV
PVAGRSGIAT IKASLANMRD GGFISAHDFL IASRIAEAVC GGDVEAGSLV SEEWLLALER
KAFVDLLGTG KTQERIMGML QTGKPVRN
//