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Database: UniProt
Entry: H1VB37_COLHI
LinkDB: H1VB37_COLHI
Original site: H1VB37_COLHI 
ID   H1VB37_COLHI            Unreviewed;       828 AA.
AC   H1VB37;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   03-JUL-2019, entry version 43.
DE   SubName: Full=Urease {ECO:0000313|EMBL:CCF37440.1};
DE   Flags: Fragment;
GN   ORFNames=CH063_08768 {ECO:0000313|EMBL:CCF37440.1};
OS   Colletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Glomerellales; Glomerellaceae;
OC   Colletotrichum.
OX   NCBI_TaxID=759273 {ECO:0000313|Proteomes:UP000007174};
RN   [1] {ECO:0000313|Proteomes:UP000007174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMI 349063 {ECO:0000313|Proteomes:UP000007174};
RX   PubMed=22885923; DOI=10.1038/ng.2372;
RA   O'Connell R.J., Thon M.R., Hacquard S., Amyotte S.G., Kleemann J.,
RA   Torres M.F., Damm U., Buiate E.A., Epstein L., Alkan N.,
RA   Altmueller J., Alvarado-Balderrama L., Bauser C.A., Becker C.,
RA   Birren B.W., Chen Z., Choi J., Crouch J.A., Duvick J.P., Farman M.A.,
RA   Gan P., Heiman D., Henrissat B., Howard R.J., Kabbage M., Koch C.,
RA   Kracher B., Kubo Y., Law A.D., Lebrun M.-H., Lee Y.-H., Miyara I.,
RA   Moore N., Neumann U., Nordstroem K., Panaccione D.G., Panstruga R.,
RA   Place M., Proctor R.H., Prusky D., Rech G., Reinhardt R.,
RA   Rollins J.A., Rounsley S., Schardl C.L., Schwartz D.C., Shenoy N.,
RA   Shirasu K., Sikhakolli U.R., Stueber K., Sukno S.A., Sweigard J.A.,
RA   Takano Y., Takahara H., Trail F., van der Does H.C., Voll L.M.,
RA   Will I., Young S., Zeng Q., Zhang J., Zhou S., Dickman M.B.,
RA   Schulze-Lefert P., Ver Loren van Themaat E., Ma L.-J.,
RA   Vaillancourt L.J.;
RT   "Lifestyle transitions in plant pathogenic Colletotrichum fungi
RT   deciphered by genome and transcriptome analyses.";
RL   Nat. Genet. 44:1060-1065(2012).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCF37440.1}.
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DR   EMBL; CACQ02002462; CCF37440.1; -; Genomic_DNA.
DR   STRING; 80884.CCF37440; -.
DR   EnsemblFungi; CCF37440; CCF37440; CH063_08768.
DR   Proteomes; UP000007174; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007174};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007174}.
FT   DOMAIN      392    828       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    583    583       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       397    397       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       399    399       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       480    480       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       480    480       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       509    509       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       535    535       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       623    623       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     482    482       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     480    480       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:CCF37440.1}.
SQ   SEQUENCE   828 AA;  88732 MW;  4FA98BC95780BB86 CRC64;
     LDKLVISQLG SIAQRRLARG VKLNHSEATA LIASNLQELI RDGNHTVADL MSLGATMLGR
     RHVLPSVCST LHEIQVEGTF PSGTYLVTVH NPIATDDGDL ARALYGSFLP VPSNDLFAVP
     EAAAYEPKRA PGAVVTAARK VTLNGTRKRI RLRVKSKGDR PIQVGSHYHF IETNPQLEFD
     REKSYGYRLD IPAGTSVRFE PGDVKTVTLV EIGGNRVLRG GXRLASGGVE LWRASEIVEK
     LQLAGFAHAP EPEAIMDFAE AYQMERAAYA TMFGPTVDDI IRLGNTDLWI KVEKDFTVYG
     DECKFGGGKT LREGMGQATG RPDAETLDMV VTNALVVDWT GIYKADIGVK DGMIVGIGKA
     GNPDVMDGVT PNMVVGSCTD VVAGEGKIIT AGGVDSHIHF ICPQQANEAI ASGITTMLGG
     GTGPSAGTCA TTCTPGKNYM RDMLQACDML PLNIGITGKG NDSAPEALRE QVLAGACGLK
     LHEDWGTTPA AIDTCLSVCD ELDVQCLIHT DTLNESGFVE STINAFAGRT IHTYHTEGAG
     GGHAPDIISV VEHPNVLPSS TNPTRPYTRN TLDEHLDMLM VCHHLSKNIP EDVAFAESRI
     RAETIAAEDV LHDLGAISMM SSDSQAMGRC GEVILRTWNT AHKNKVQRGF LAEDEGTGAD
     NLRVKRYVSK YTINPAIAQG FGHLVGSIEV GKLADLVVWD PAWFGTKPTL VIKSGLIASA
     QMGDPNASIP TVQPIIARPM FAPLVPATSV LFVSEASISS GAIASYGLRK RVEAVKGCRN
     IGKKDMRFND SMPKMRVDPE SYVVEADGVV CEAAPAETLP LTQTFYVY
//
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