ID   H1YEC1_9SPHI            Unreviewed;       541 AA.
AC   H1YEC1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Peptidase S8 and S53 subtilisin kexin sedolisin {ECO:0000313|EMBL:EHQ26184.1};
GN   ORFNames=Mucpa_2044 {ECO:0000313|EMBL:EHQ26184.1};
OS   Mucilaginibacter paludis DSM 18603.
OC   Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Mucilaginibacter.
OX   NCBI_TaxID=714943 {ECO:0000313|EMBL:EHQ26184.1, ECO:0000313|Proteomes:UP000002774};
RN   [1] {ECO:0000313|EMBL:EHQ26184.1, ECO:0000313|Proteomes:UP000002774}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18603 {ECO:0000313|EMBL:EHQ26184.1,
RC   ECO:0000313|Proteomes:UP000002774};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Held B.,
RA   Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Brambilla E.,
RA   Klenk H.-P., Eisen J.A.;
RT   "The permanent draft genome of Mucilaginibacter paludis DSM 18603.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
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DR   EMBL; CM001403; EHQ26184.1; -; Genomic_DNA.
DR   AlphaFoldDB; H1YEC1; -.
DR   STRING; 714943.Mucpa_2044; -.
DR   eggNOG; COG1404; Bacteria.
DR   HOGENOM; CLU_022359_0_0_10; -.
DR   Proteomes; UP000002774; Chromosome.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 2.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000002774};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          103..511
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        110
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        309
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        478
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   541 AA;  60001 MW;  30F17C1C6F7C780D CRC64;
     MSKNRRLFSR PLTNTNKIKV IILTVLLLYT RNNDAGIEIS KIATTKMIRL TKLILIAVGT
     LTCFNVFGQQ IPNWQNKDLQ KDILFGISTE KAYSLLQGKK ATKITVAVID AGIDTIHEDL
     KSILWINPKK EAFDNGTYGW SYLGSPKGNV HYDNLEVTRQ VRQFEQRDTS KLPASDLLAY
     HAEKQVLQRQ LSEAQRMVDG MGNFRRILES VVQKIGKPEP KLADFQTYQP LGPGETQVCQ
     TLIKVLTEKD DYKSFKEEQL DSPMEHFKVQ SDYQLNTGYD PRIIIGDDYF NSKQHKYGSS
     DVMGPDATHG THVAGIIAAV RNNGIGLDGI ADNVQILTVR AVPDGDERDK DVANAIRYAT
     DHGAKVINMS FGKDYSQDKK AVDEAIQYAL KKDVLLIQAA GNSNKNIDSA ANFPNRKYIN
     GKIAGAYIVV GASGLKDDDH LKAGFSNYGK TSVDVFAPGV QIYSTIPGSK YAYFDGTSMA
     CPVVSGLAAL IREYYPKLTA LEVKEIILKS VVKRSALTNY CITGGVVNIY NALQLAEKYQ
     K
//